{"id":"W4404861219","doi":"10.1096/fj.202401145rr","title":"The <scp>AMPK</scp> allosteric activator <scp>MK</scp> ‐8722 improves the histology and spliceopathy in myotonic dystrophy type 1 ( <scp>DM1</scp> ) skeletal muscle","year":2024,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"French Muscular Dystrophy Association; Muscular Dystrophy Association","keywords":"AMPK; Endocrinology; Allosteric regulation; Internal medicine; Chemistry; Skeletal muscle; Activator (genetics); Protein kinase A; AMP-activated protein kinase; Muscular dystrophy; Phosphorylation; Biology; Medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001860392,0.0006084916,0.0007434977,0.0003567874,0.0001504256,0.0002448257,0.0003276186,0.0004096942,0.002390424],"category_scores_gemma":[0.0000928809,0.0002051266,0.000394204,0.0002031707,0.0003388305,0.0001879054,0.0001827872,0.001229291,0.000624483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002247436,"about_ca_system_score_gemma":0.0002605802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008731252,"about_ca_topic_score_gemma":0.002001554,"domain_scores_codex":[0.9998013,0.00003416438,0.00003225202,0.00003169706,0.00005139217,0.00004914381],"domain_scores_gemma":[0.9998816,0.00001494109,0.00004107025,0.00001383862,0.00001079599,0.00003762712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001043607,0.000257711,0.0001529718,0.00008821992,0.0000199669,0.00003744619,0.00001012214,0.0000964139,0.9963412,0.00004077137,0.0001495357,0.001762014],"study_design_scores_gemma":[0.0001948227,0.004559411,0.008315849,0.00001827542,0.00007103787,0.0002260503,0.00004612056,0.0008703349,0.9838126,0.00002907822,0.001844689,0.00001173768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958151,0.001344249,0.0007992324,0.0001798825,0.00007708422,0.00004237087,0.0005811657,0.0001987678,0.000962246],"genre_scores_gemma":[0.9916323,0.001545315,0.002114482,0.0001720424,0.00004057203,0.00009247736,0.0009369868,0.00005635587,0.003409462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002390424,"threshold_uncertainty_score":0.007996738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754345750775919,"score_gpt":0.2481740352137279,"score_spread":0.2306305777059687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}