{"id":"W4404866681","doi":"10.1101/2024.11.25.24317901","title":"Clinical Validation of Metabolite Markers for Early Lung Cancer Detection","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; St. Boniface Hospital; CancerCare Manitoba; University of Manitoba; The Metabolomics Innovation Centre; Université Laval; University of Alberta","funders":"","keywords":"Metabolite; Lung cancer; Medicine; Internal medicine; Computational biology; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006536214,0.0008094392,0.0008111932,0.0008369628,0.000317402,0.001529201,0.0004964843,0.0007903764,0.001055222],"category_scores_gemma":[0.01165158,0.000299298,0.0004678299,0.0006275373,0.0005101723,0.0004239749,0.0005717081,0.0006285767,0.000558983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003488559,"about_ca_system_score_gemma":0.0005947489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005267253,"about_ca_topic_score_gemma":0.0005490852,"domain_scores_codex":[0.996874,0.00180768,0.0001877234,0.0004570097,0.0005755897,0.00009788472],"domain_scores_gemma":[0.994531,0.002644404,0.001177866,0.0005652905,0.0008631537,0.0002184229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003823241,0.0003960781,0.8792714,0.000286195,0.0006222777,0.0003032423,0.0001071788,0.002482498,0.05502796,0.0003733303,0.00187843,0.05542818],"study_design_scores_gemma":[0.0003494149,0.003726489,0.8259824,0.0001760898,0.0009040225,0.002189046,0.0002279027,0.03322439,0.1241178,0.002543505,0.006474398,0.00008453183],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9619243,0.00897321,0.02299367,0.00122857,0.0002009197,0.0001846962,0.002331302,0.000362515,0.001800944],"genre_scores_gemma":[0.9926832,0.0005030248,0.005450816,0.0002528092,0.00006613401,0.00004071702,0.0006963619,0.00002318955,0.0002837562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006536214,"threshold_uncertainty_score":0.03456724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02177803828620868,"score_gpt":0.3450811861822077,"score_spread":0.323303147895999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}