{"id":"W4404867374","doi":"10.1097/coc.0000000000001157","title":"Phase 2, Multicenter, Open-label, Nonrandomized Study of Neoadjuvant Chemotherapy Liposomal Irinotecan With 5-Fluorouracil, Leucovorin, and Oxaliplatin, Followed by Chemoradiotherapy in Patients With Rectal Cancer in a Watch-and-Wait Program","year":2024,"lang":"en","type":"article","venue":"American Journal of Clinical Oncology","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Irinotecan; Oxaliplatin; Internal medicine; Fluorouracil; Capecitabine; Phases of clinical research; Clinical endpoint; Colorectal cancer; Chemotherapy; Gastroenterology; Chemoradiotherapy; Neoadjuvant therapy; Surgery; Oncology; Cancer; Clinical trial; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004568757,0.003126621,0.002801063,0.0006782932,0.0006475337,0.001055813,0.001126538,0.00160549,0.003259437],"category_scores_gemma":[0.0024267,0.001229223,0.001402616,0.0005701546,0.002059469,0.001477725,0.0005979431,0.002949001,0.0007416995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001230785,"about_ca_system_score_gemma":0.002687403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007606464,"about_ca_topic_score_gemma":0.00197601,"domain_scores_codex":[0.9976471,0.001638953,0.00008192032,0.0002849533,0.0001397805,0.0002073366],"domain_scores_gemma":[0.997826,0.0003939996,0.0005409263,0.0002802943,0.0001459064,0.0008126991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8775759,0.09777621,0.003581146,0.0001895341,0.0004961666,0.00008300373,0.0001269792,0.0007988967,0.009634351,0.00008697173,0.0005176386,0.009133236],"study_design_scores_gemma":[0.652144,0.3429912,0.002705707,0.000009461578,0.0001452396,0.00004558189,0.00002471673,0.0005848231,0.0009548886,0.00005105758,0.0003304218,0.00001282884],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994926,0.0003816709,0.0004801441,0.0001831019,0.0001350965,0.003255759,0.0002426393,0.00003749792,0.0003581214],"genre_scores_gemma":[0.9822613,0.0006530798,0.003342511,0.0007632961,0.0005511197,0.009409202,0.001157724,0.00003370674,0.001828094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004568757,"threshold_uncertainty_score":0.02416217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04009671034176392,"score_gpt":0.4576771838341635,"score_spread":0.4175804734923996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}