{"id":"W4404883387","doi":"10.1002/alz.14264","title":"ADNI Biomarker Core: A review of progress since 2004 and future challenges","year":2024,"lang":"en","type":"review","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Biobank; Biomarker; Biomarker discovery; Alzheimer's Disease Neuroimaging Initiative; Medicine; Disease; Bioinformatics; Internal medicine; Alzheimer's disease; Proteomics; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004555424,0.001199441,0.002435135,0.00557747,0.000395086,0.001936165,0.001772213,0.001994593,0.003402495],"category_scores_gemma":[0.006305365,0.0006050374,0.001336587,0.005560662,0.0006869291,0.00280865,0.00116278,0.002440637,0.002297161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001867596,"about_ca_system_score_gemma":0.005769192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003762167,"about_ca_topic_score_gemma":0.006083306,"domain_scores_codex":[0.9989367,0.0002667814,0.0002637971,0.0001550808,0.0003102047,0.00006745369],"domain_scores_gemma":[0.9956847,0.002045434,0.0005821518,0.00008610105,0.001402409,0.0001991568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001169533,0.00005059651,0.0002092997,0.04667702,0.0001605871,0.0001058372,0.00008136375,0.0001847892,0.0003642396,0.002609381,0.04667023,0.9027697],"study_design_scores_gemma":[0.00003137087,0.0001492985,0.0009563955,0.03454993,0.0003691536,0.0007530381,0.00009777372,0.00008554921,0.0002560549,0.001299997,0.9614193,0.00003199833],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003179141,0.9987185,0.00006396736,0.0006229026,0.0001719368,0.000007688168,0.00002857651,0.000005576765,0.0003490354],"genre_scores_gemma":[0.0002359653,0.9987601,0.000243081,0.0004060215,0.0001464235,0.00001436704,0.00004902208,0.000002392119,0.0001426806],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00557747,"threshold_uncertainty_score":0.02409166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.098823496708935,"score_gpt":0.4061590549160132,"score_spread":0.3073355582070781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}