{"id":"W4404899992","doi":"10.1111/febs.17333","title":"Oxidative pathways of apo, partially, and fully Zn(<scp>II</scp>)‐ and Cd(<scp>II</scp>)‐metalated human metallothionein‐3 are dominated by disulfide bond formation","year":2024,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Trace Elements in Health","field":"Nursing","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Oxidative stress; Reactive oxygen species; Metallothionein; Oxidative phosphorylation; Electrospray ionization; Antioxidant; Cysteine; Hydrogen peroxide; Circular dichroism; Biochemistry; Biophysics; Enzyme; Mass spectrometry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001750146,0.0005333047,0.0007922999,0.0005473949,0.001386568,0.0004538108,0.0003076865,0.0003157517,0.00001984035],"category_scores_gemma":[0.0007955852,0.0004819458,0.000183902,0.0005960254,0.000279261,0.001671563,0.0002389449,0.001219522,0.0000152131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002738337,"about_ca_system_score_gemma":0.0001051339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004513645,"about_ca_topic_score_gemma":0.0001126516,"domain_scores_codex":[0.9957548,0.0004334699,0.001491154,0.0005862019,0.0008504798,0.0008839292],"domain_scores_gemma":[0.9970821,0.0007133161,0.00106062,0.0003271006,0.0003224362,0.0004943937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001633722,0.0008615573,0.004271342,0.001367835,0.001067139,0.0002302448,0.04168719,0.00006920459,0.8476555,0.001621929,0.07983404,0.02117067],"study_design_scores_gemma":[0.007369291,0.004860197,0.03983957,0.002908387,0.001451576,0.001663732,0.01576909,0.004079333,0.8503276,0.01655924,0.05461282,0.0005591221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891012,0.006426256,0.0008971281,0.0007937694,0.001142703,0.0006918376,0.0002323147,0.0001883498,0.0005264724],"genre_scores_gemma":[0.9970248,0.0004784405,0.001334291,0.0001707722,0.0002969863,0.00002640516,0.0001208074,0.0001056137,0.0004419294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03556823,"threshold_uncertainty_score":0.9999135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02142694455981326,"score_gpt":0.2845899499128192,"score_spread":0.2631630053530059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}