{"id":"W4404902368","doi":"10.1016/j.nucmedbio.2024.108986","title":"Transmembrane protein 106B amyloid is a potential off-target molecule of tau PET tracers in the choroid plexus","year":2024,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Science and Technology Agency; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development","keywords":"Choroid plexus; Transmembrane protein; Chemistry; Amyloid (mycology); Biophysics; Neuroscience; Biochemistry; Biology; Central nervous system; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003260218,0.0007082337,0.0004515593,0.0004268656,0.0003885664,0.0005147927,0.0002758855,0.0008110764,0.001155477],"category_scores_gemma":[0.0003101675,0.0003924372,0.0003437728,0.0002265672,0.0003516982,0.0003786861,0.0002700483,0.0004831847,0.0006471688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004735173,"about_ca_system_score_gemma":0.0002566837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002527296,"about_ca_topic_score_gemma":0.001914879,"domain_scores_codex":[0.9997506,0.00008235141,0.00001081903,0.00005696444,0.00004867471,0.0000507092],"domain_scores_gemma":[0.9998507,0.00004278051,0.00003737113,0.00001412969,0.00002593983,0.00002894556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000884719,0.000007966565,0.0003914535,0.0000511793,0.000007400854,0.0004244926,0.00003375439,0.00006448953,0.9973373,0.0001186981,0.0000416742,0.001433194],"study_design_scores_gemma":[0.0000193443,0.0006211621,0.02307343,0.00004714441,0.00004758949,0.00533905,0.000145565,0.002797779,0.960855,0.0003517159,0.006678715,0.00002351377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97197,0.009371379,0.01164491,0.0002401078,0.000030984,0.00005136581,0.0001733986,0.0001464939,0.00637141],"genre_scores_gemma":[0.9818074,0.003086522,0.01037184,0.0001087522,0.00001747669,0.00004560166,0.0002645437,0.0000446017,0.004253356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002527296,"threshold_uncertainty_score":0.005025148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02655741832414101,"score_gpt":0.3165028626940757,"score_spread":0.2899454443699347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}