{"id":"W4404905120","doi":"10.1001/jamapediatrics.2024.5059","title":"Clinical Actionability of Genetic Findings in Cerebral Palsy","year":2024,"lang":"en","type":"review","venue":"JAMA Pediatrics","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Holland Bloorview Kids Rehabilitation Hospital; SickKids Foundation; Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke","keywords":"Medicine; Etiology; Exome sequencing; Psychological intervention; Genetic testing; Bioinformatics; Genetics; Phenotype; Gene; Internal medicine; Psychiatry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1561899,0.0007252151,0.002027061,0.01518289,0.0007595276,0.00304748,0.002389936,0.001764595,0.003418804],"category_scores_gemma":[0.3230588,0.0005339374,0.003334112,0.0100435,0.003909359,0.00382625,0.003703048,0.001402686,0.0003224055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003408788,"about_ca_system_score_gemma":0.01037792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002489264,"about_ca_topic_score_gemma":0.005118386,"domain_scores_codex":[0.7646862,0.1428909,0.05722253,0.008202406,0.02598391,0.001014104],"domain_scores_gemma":[0.5109212,0.3960547,0.06119543,0.007307912,0.02343034,0.001090447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001776044,0.0001332433,0.1880685,0.2732849,0.008388111,0.002228719,0.009366493,0.002228618,0.001704541,0.009099817,0.01317316,0.4905479],"study_design_scores_gemma":[0.0008201973,0.001579406,0.3949591,0.4542683,0.01772237,0.007858223,0.01406181,0.003065478,0.003610913,0.03793241,0.06357639,0.0005454326],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2224081,0.6126312,0.03932684,0.04412865,0.00240991,0.01181908,0.02778007,0.0002367085,0.03925931],"genre_scores_gemma":[0.8376167,0.09621232,0.04692385,0.005164583,0.0009362578,0.006433597,0.006126422,0.00004497313,0.0005413237],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1561899,"threshold_uncertainty_score":0.8260212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03140602300532411,"score_gpt":0.3555707490128939,"score_spread":0.3241647260075697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}