{"id":"W4404908668","doi":"10.1021/acs.jafc.4c09504","title":"Combinatorial Targeting of Common Docking and ATP Binding Sites on Mps1 MAPK for Management of Pathogenic Fungi","year":2024,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Fungal Plant Pathogen Control","field":"Agricultural and Biological Sciences","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Ministry of Science and Technology of the People's Republic of China; China Agricultural University","keywords":"Docking (animal); Fungal pathogen; Binding site; Kinase; Chemistry; Fungicide; MAPK/ERK pathway; Mechanism of action; In vivo; Biochemistry; Pathogen; Biology; In vitro; Microbiology; Biotechnology; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215305,0.0001368571,0.0002871602,0.000009402941,0.00007547475,0.00005217873,0.0001188359,0.00008311434,0.00001232631],"category_scores_gemma":[0.00001594995,0.00004815315,0.0001521385,0.0001229597,0.00002854421,0.00009663506,0.00005154756,0.0001394764,2.139577e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001610939,"about_ca_system_score_gemma":0.000003002081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001248817,"about_ca_topic_score_gemma":8.436743e-7,"domain_scores_codex":[0.9990901,0.0000146076,0.0003995903,0.000146894,0.0001968701,0.0001519138],"domain_scores_gemma":[0.9992968,0.0002577773,0.0002713052,0.0000204748,0.00008224121,0.00007133441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006889782,0.00004864539,0.0005809388,0.0004373528,0.0001300949,0.000007612597,0.0000591685,0.000006451069,0.9949712,0.0001606083,0.0001698737,0.003359125],"study_design_scores_gemma":[0.0008600291,0.001601678,0.02699984,0.001296975,0.0002655712,0.0002002547,0.001750191,0.00005520313,0.9651968,0.000405762,0.001069478,0.0002981908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950541,0.0041517,4.228789e-7,0.0001919481,0.0001690153,0.0001072008,0.0001563462,0.000009130094,0.0001601711],"genre_scores_gemma":[0.9992486,0.000217182,0.00007201259,0.000006728857,0.0003835338,0.00000229488,0.00003466375,0.000001091025,0.0000338463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02977441,"threshold_uncertainty_score":0.1963628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146942935085245,"score_gpt":0.2012930175437667,"score_spread":0.1898235881929143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}