{"id":"W4404926477","doi":"10.1136/jitc-2024-009462","title":"Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma","year":2024,"lang":"en","type":"review","venue":"Journal for ImmunoTherapy of Cancer","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Cilag; Medac; Swedish Orphan Biovitrum; Else Kröner-Fresenius-Stiftung; Incyte; Eli Lilly and Company; AstraZeneca; CSL Behring; Gilead Sciences; BeiGene; Sanofi; Amgen; Pfizer; Les Laboratories Pierre Fabre; Celgene","keywords":"Medicine; Chimeric antigen receptor; Immune system; T cell; Immunotherapy; Immunosenescence; Immunology; Multiple myeloma; Naive T cell; Senescence; Cancer research; Internal medicine; T-cell receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005678282,0.0002080282,0.000431024,0.0004777917,0.0001744761,0.0004439802,0.0001755843,0.0005200139,0.001028079],"category_scores_gemma":[0.0009875628,0.00005160435,0.000312637,0.0004242198,0.0001727728,0.0004363402,0.000322206,0.00062145,0.000278145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003195976,"about_ca_system_score_gemma":0.0004995901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005335428,"about_ca_topic_score_gemma":0.001313193,"domain_scores_codex":[0.9997653,0.00008377715,0.00004467407,0.00002539637,0.00005564834,0.00002511596],"domain_scores_gemma":[0.9994805,0.0002530561,0.0001202647,0.000006519289,0.0000950705,0.00004458364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003761725,0.00005960428,0.004331012,0.009221573,0.000178974,0.0004725211,0.0001263439,0.0002172057,0.002108866,0.001402444,0.0207695,0.9607356],"study_design_scores_gemma":[0.0001218237,0.001323985,0.03319604,0.01086168,0.001269086,0.006772225,0.0003121643,0.0002984052,0.002107166,0.002198887,0.9414979,0.00004070809],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002141236,0.9949491,0.0001354544,0.001462479,0.0002486942,0.000005807934,0.00003008587,0.000007854597,0.00101919],"genre_scores_gemma":[0.02075348,0.9756806,0.0002981226,0.001589777,0.001019237,0.00002037972,0.00007918198,0.000002641545,0.000556618],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001028079,"threshold_uncertainty_score":0.003439307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03172640834317397,"score_gpt":0.3880485864161476,"score_spread":0.3563221780729737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}