{"id":"W4404940205","doi":"10.1111/1440-1681.70012","title":"Fingolimod Inhibits <scp>C6</scp> Rat Glioma Proliferation and Migration, Induces Sub‐<scp>G1</scp> Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo","year":2024,"lang":"en","type":"article","venue":"Clinical and Experimental Pharmacology and Physiology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Clinical Research Institute","funders":"Iran National Science Foundation","keywords":"Fingolimod; Apoptosis; Cell cycle; Annexin; Cell cycle checkpoint; Cell growth; Biology; Cancer research; Molecular biology; Cell biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220012,0.0006584674,0.0003712437,0.0004887462,0.0001651917,0.0001852934,0.0002051651,0.0003400455,0.001484799],"category_scores_gemma":[0.0000849339,0.00009526437,0.0004772189,0.0002713129,0.0001696452,0.0001251457,0.0001110509,0.0007092651,0.0005508612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002917008,"about_ca_system_score_gemma":0.0003666846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001245223,"about_ca_topic_score_gemma":0.002394008,"domain_scores_codex":[0.9998931,0.00001327046,0.000009108813,0.00001351253,0.00004143198,0.00002956103],"domain_scores_gemma":[0.9999418,0.000006544155,0.00002111851,0.000007151779,0.00001009926,0.00001330196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004798153,0.0001758147,0.0001501258,0.0001067445,0.0000169635,0.00009509325,0.00001140007,0.0001108772,0.9918963,0.00007614457,0.0002463301,0.006634494],"study_design_scores_gemma":[0.0000501532,0.001638914,0.003074469,0.000008253214,0.00002767705,0.0004399213,0.00001456332,0.0005352749,0.9904298,0.00003482718,0.003740547,0.000005617199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878674,0.005670524,0.001997225,0.0002050763,0.00006161879,0.00006574404,0.001046854,0.0002680808,0.002817594],"genre_scores_gemma":[0.9834434,0.006829422,0.002679993,0.00009485266,0.00003610423,0.00008368905,0.002402211,0.00004270544,0.0043877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484799,"threshold_uncertainty_score":0.004967213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01260358213191414,"score_gpt":0.2954165373108874,"score_spread":0.2828129551789733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}