{"id":"W4404945099","doi":"10.1182/bloodadvances.2024013267","title":"Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans","year":2024,"lang":"en","type":"article","venue":"Blood Advances","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Pfizer; Broad Institute; AstraZeneca; National Institutes of Health; Bristol-Myers Squibb","keywords":"Immunoglobulin D; B cell; Cell biology; CD40; Biology; T cell; mTORC1; Cell; Immunology; Immune system; Signal transduction; Cytotoxic T cell; In vitro; Antibody; PI3K/AKT/mTOR pathway; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793449,0.0005317942,0.0003605696,0.0007486541,0.0003855114,0.0003877767,0.0002055242,0.0004790159,0.002755325],"category_scores_gemma":[0.0004147016,0.000178994,0.0001876617,0.0003360932,0.000386281,0.0001749784,0.0003262594,0.0003915223,0.0004677456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331974,"about_ca_system_score_gemma":0.0001555356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006192547,"about_ca_topic_score_gemma":0.0002860907,"domain_scores_codex":[0.9998159,0.00005030348,0.00001598574,0.000066875,0.00002230282,0.00002864886],"domain_scores_gemma":[0.9998846,0.00002425138,0.0000368373,0.00001636003,0.000008325519,0.00002959788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01079799,0.001244491,0.2451565,0.000328578,0.000248478,0.02793627,0.0006987204,0.0005626611,0.639231,0.001770608,0.002308454,0.06971623],"study_design_scores_gemma":[0.0005860389,0.008655933,0.6350425,0.0001735441,0.0005888776,0.163702,0.0005252758,0.00189307,0.1701833,0.001569736,0.01699759,0.00008210506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997241,0.000945389,0.0006094863,0.00005146542,0.00001086265,0.00001424647,0.0001972747,0.00006465591,0.0008656873],"genre_scores_gemma":[0.9988758,0.0003298389,0.0002667883,0.00003065774,0.000008985937,0.000009808582,0.0001702996,0.00001291923,0.0002949362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002755325,"threshold_uncertainty_score":0.009217441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00660035695546517,"score_gpt":0.2223655247720137,"score_spread":0.2157651678165486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}