{"id":"W4404945958","doi":"10.1162/imag_a_00405","title":"Domain-specific cognitive impairment is differentially affected by Alzheimer disease tau pathologic burden and spread","year":2024,"lang":"en","type":"article","venue":"Imaging Neuroscience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Dementias Platform UK; Fleni; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Institute of General Medical Sciences; Korea Health Industry Development Institute; Prothena; Avid Radiopharmaceuticals; Foundation for Barnes-Jewish Hospital; Japan Agency for Medical Research and Development; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Ministry of Science and ICT, South Korea; Fondation Brain Canada; BrightFocus Foundation; Eli Lilly and Company; Bristol-Myers Squibb; Eisai; National Institute on Aging; Alzheimer's Association","keywords":"Cognitive impairment; Disease; Alzheimer's disease; Cognition; Domain (mathematical analysis); Neuroscience; Medicine; Psychology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004951438,0.0005388018,0.0004507118,0.001169599,0.0002438105,0.0006061543,0.0002284372,0.0003565745,0.001358712],"category_scores_gemma":[0.002462898,0.000175197,0.0003096572,0.0006196883,0.0002903839,0.0004609101,0.0005971162,0.0003522404,0.0002707415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000175981,"about_ca_system_score_gemma":0.0001126186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001571788,"about_ca_topic_score_gemma":0.002125233,"domain_scores_codex":[0.9997758,0.00003642733,0.00002712769,0.00007021887,0.00006251331,0.00002778634],"domain_scores_gemma":[0.9987,0.0001740493,0.0006698857,0.000123744,0.0001644026,0.0001677866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001678161,0.0001152604,0.9795461,0.00003407563,0.0002770388,0.000310951,0.0002819861,0.0004226021,0.008709754,0.00004663053,0.0001246451,0.008452844],"study_design_scores_gemma":[0.000003416487,0.0000793306,0.999069,0.000003528315,0.0000156302,0.0002456616,0.00005109884,0.0001832448,0.0002390806,0.00007290491,0.00003385053,0.000003311519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992481,0.0001733508,0.0001224934,0.000007833958,0.000001779623,0.000004338585,0.0001046242,0.00000604891,0.0003313569],"genre_scores_gemma":[0.999629,0.00004009308,0.0000736249,0.000005587911,0.000003634799,0.000002611935,0.0001293169,0.000001974921,0.0001140183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001571788,"threshold_uncertainty_score":0.004545391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931644627490168,"score_gpt":0.3116303897883092,"score_spread":0.2923139435134075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}