{"id":"W4404950115","doi":"10.1021/acs.est.4c07149","title":"Contrasting Kinetics of Highly Similar Chloroalkane Reductive Dehalogenases","year":2024,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Microbial bioremediation and biosurfactants","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Ontario","keywords":"Dehalogenase; Chemistry; Dehalococcoides; Bioremediation; Reductive dechlorination; Enzyme; Substrate (aquarium); Chloroform; Active site; Biocatalysis; Environmental remediation; Vinyl chloride; Stereochemistry; Bacteria; Biochemistry; Catalysis; Organic chemistry; Biodegradation; Reaction mechanism; Contamination; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003624173,0.0003330555,0.0004297429,0.0004037817,0.00009865334,0.0007430911,0.000299193,0.0004507985,0.0005754037],"category_scores_gemma":[0.000819337,0.0002362491,0.0003778517,0.0004947671,0.0001660457,0.0004205077,0.000292507,0.0005541809,0.0003347943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000337215,"about_ca_system_score_gemma":0.0002347152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00212775,"about_ca_topic_score_gemma":0.001427134,"domain_scores_codex":[0.9994053,0.00006900404,0.00006912417,0.0001699528,0.0001502925,0.0001364616],"domain_scores_gemma":[0.999549,0.0001099854,0.00009423793,0.00004221786,0.0001461502,0.00005835779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001269035,0.00003518956,0.002473235,0.00003985679,0.00001590068,0.00002243033,0.00006983673,0.0002102477,0.9940561,0.00009974166,0.00002859274,0.002821863],"study_design_scores_gemma":[0.000007936701,0.000318567,0.0312285,0.000006620013,0.00002654637,0.0002362449,0.0001934849,0.003276849,0.9628708,0.00009238454,0.001715568,0.00002655559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950772,0.0009205525,0.002499438,0.00004937375,0.0000103694,0.00002018637,0.0005825113,0.00005194615,0.0007884615],"genre_scores_gemma":[0.9910594,0.0007698664,0.003848306,0.00003060803,0.000005998207,0.00003650903,0.002193772,0.00002986765,0.002025711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00212775,"threshold_uncertainty_score":0.004230738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005454700905580324,"score_gpt":0.2083169371293269,"score_spread":0.2028622362237466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}