{"id":"W4404951253","doi":"10.26508/lsa.202403142","title":"<i>N</i> -6-methyladenosine (m6A) promotes the nuclear retention of mRNAs with intact 5′ splice site motifs","year":2024,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"N6-Methyladenosine; RNA; RNA splicing; Chemistry; Precursor mRNA; Cell biology; Biology; Molecular biology; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103656,0.0001513607,0.0001101723,0.0001049123,0.0002042705,0.0001691941,0.0001181296,0.0001604792,0.00113857],"category_scores_gemma":[0.00008221405,0.00008923857,0.0001451244,0.00006557979,0.0001605434,0.00009170722,0.0001798478,0.000236929,0.000373534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002186349,"about_ca_system_score_gemma":0.0001422768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006875785,"about_ca_topic_score_gemma":0.001354222,"domain_scores_codex":[0.9999393,0.000009672845,0.000003483838,0.00001935899,0.00001619616,0.00001194472],"domain_scores_gemma":[0.9999142,0.00001021605,0.0000307176,0.00001014541,0.00000781858,0.00002688364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006681115,0.00001076164,0.0003406014,0.00001493397,0.000002180147,0.00002899216,0.000007668807,0.00002544747,0.9975972,0.00009777206,0.00004732924,0.001760251],"study_design_scores_gemma":[0.000007884605,0.0002639146,0.0108931,0.000003591882,0.000005845544,0.0002828651,0.00001361042,0.0002638973,0.9829959,0.00006146434,0.005205076,0.000002949942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893344,0.00386004,0.002977152,0.0001537113,0.0000307145,0.00001819094,0.0002366216,0.0001658994,0.003223242],"genre_scores_gemma":[0.9954684,0.0008000158,0.001556682,0.00003698131,0.000007929487,0.000008460849,0.0001672312,0.00001023334,0.001943999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00113857,"threshold_uncertainty_score":0.003808916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177872428878035,"score_gpt":0.2516612467421878,"score_spread":0.2398825224534075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}