{"id":"W4404957810","doi":"10.1038/s41593-024-01814-0","title":"Implementation and validation of single-cell genomics experiments in neuroscience","year":2024,"lang":"en","type":"review","venue":"Nature Neuroscience","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Neuroscience; Computational biology; Relevance (law); Nucleus; Functional genomics; Cell type; Single-cell analysis; Genomics; Biology; Cell; Transcriptome; Computer science; Gene expression; Gene; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01306813,0.001814278,0.00329521,0.001926947,0.0003690506,0.002984552,0.004079263,0.003077019,0.00222439],"category_scores_gemma":[0.007857398,0.0009633004,0.001090229,0.001881685,0.003714726,0.003225042,0.002148423,0.005018692,0.002381727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002600025,"about_ca_system_score_gemma":0.003460837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001729547,"about_ca_topic_score_gemma":0.001711859,"domain_scores_codex":[0.9970109,0.000806154,0.0002063525,0.0006015796,0.001181746,0.0001931715],"domain_scores_gemma":[0.9898028,0.006744073,0.0003495942,0.0008140749,0.00199407,0.0002954311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001725306,0.0001261166,0.0005634749,0.01144644,0.0001819378,0.0002277489,0.0001130326,0.00310959,0.02731564,0.07101161,0.02932421,0.8564076],"study_design_scores_gemma":[0.00005963882,0.0002128713,0.00249381,0.004032489,0.000210236,0.001026924,0.0001080917,0.003209158,0.02498269,0.05187323,0.9116805,0.0001104375],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009137874,0.9138429,0.07367145,0.003206688,0.002251978,0.0001204949,0.0003943096,0.0003098468,0.005288596],"genre_scores_gemma":[0.00764992,0.927735,0.0569839,0.002546893,0.001341855,0.0002516773,0.0006554674,0.0001263572,0.002708788],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01306813,"threshold_uncertainty_score":0.06911176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04606156506954733,"score_gpt":0.3533011801377943,"score_spread":0.3072396150682469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}