{"id":"W4404960577","doi":"10.3390/cells13231999","title":"Therapeutic Exploitation of Neuroendocrine Transdifferentiation Drivers in Prostate Cancer","year":2024,"lang":"en","type":"review","venue":"Cells","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Medical Research Council; Prostate Cancer Foundation","keywords":"Transdifferentiation; Prostate cancer; Cancer research; Neuroendocrine differentiation; Biology; LNCaP; Androgen receptor; Medicine; SOX2; Cancer; Transcription factor; Internal medicine; Cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004885811,0.0002183368,0.0008023778,0.000370169,0.00001138526,0.0000118539,0.00006367452,0.00004518649,0.0001274241],"category_scores_gemma":[0.000002552328,0.0001436779,0.0002417193,0.0004219259,0.00004406228,0.00004082183,0.00001468996,0.0002933891,0.00004053359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218939,"about_ca_system_score_gemma":0.0003474479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003324572,"about_ca_topic_score_gemma":0.00001258169,"domain_scores_codex":[0.9988596,0.00006818857,0.000364734,0.000279757,0.000219493,0.0002082716],"domain_scores_gemma":[0.999611,0.00003984942,0.00009486637,0.0001587343,0.00004209252,0.00005344643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004959432,0.000100814,0.0000412122,0.05193732,0.000246935,0.0001470201,0.0004570104,0.000001145836,0.0001994169,0.00001311388,0.00023253,0.9465739],"study_design_scores_gemma":[0.001955613,0.0003790241,0.0001134138,0.03651338,0.004304013,0.00001894613,0.0001124834,0.00006492097,0.001882194,0.00007346882,0.9542865,0.0002960808],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008420275,0.996912,0.000001703489,0.0001182444,0.0003273662,0.001538935,0.00007429675,0.00002284831,0.0001625966],"genre_scores_gemma":[0.001559654,0.9933282,0.000007009352,0.00001128952,0.00004705362,0.0003014176,0.0001989036,0.0000481749,0.004498325],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9540539,"threshold_uncertainty_score":0.5859013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07328815464932636,"score_gpt":0.3959958476098728,"score_spread":0.3227076929605465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}