{"id":"W4404960812","doi":"10.1002/anse.202400099","title":"pH‐Directed Capture‐SELEX for Nanomolar Affinity Aptamers for Kanamycin Detection","year":2024,"lang":"en","type":"article","venue":"Analysis & Sensing","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Systematic evolution of ligands by exponential enrichment; Kanamycin; Chemistry; Combinatorial chemistry; Chromatography; Computational biology; Molecular biology; Biology; Biochemistry; Antibiotics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004049384,0.0002533809,0.0003684224,0.0003387565,0.0002337835,0.0001054132,0.00008723418,0.000237811,0.000001579076],"category_scores_gemma":[0.0002089554,0.0002295244,0.0008296253,0.0009179043,0.00006842024,0.000008965849,0.00003243594,0.0001020426,0.000001337922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005167097,"about_ca_system_score_gemma":0.00004645834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009089692,"about_ca_topic_score_gemma":0.001102503,"domain_scores_codex":[0.9984375,0.00006778351,0.0003224362,0.0007008874,0.0001286438,0.0003427372],"domain_scores_gemma":[0.9990915,0.0000775488,0.0001089883,0.000367429,0.0002792706,0.00007526423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008219447,0.0000188924,0.00003239387,0.00003249338,0.00182604,0.00000329658,0.00003016703,0.00007006389,0.9461849,0.00001241548,0.0006003357,0.05110677],"study_design_scores_gemma":[0.0001594778,0.0001231565,0.0000504425,0.00002079013,0.002750584,0.00001021123,0.0001114529,0.07070431,0.8988663,0.0001705665,0.02669339,0.0003393049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5521019,0.0008402107,0.4455783,0.0002466398,0.0001953223,0.00043119,0.00008966011,0.0003726385,0.0001441656],"genre_scores_gemma":[0.9666553,0.00009422534,0.031676,0.0001879566,0.0003095238,0.000009777962,0.0005641455,0.00004166987,0.0004613713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4145535,"threshold_uncertainty_score":0.9359732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00983138739468,"score_gpt":0.2794927040349695,"score_spread":0.2696613166402895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}