{"id":"W4404960812","doi":"10.1002/anse.202400099","title":"pH‐Directed Capture‐SELEX for Nanomolar Affinity Aptamers for Kanamycin Detection","year":2024,"lang":"en","type":"article","venue":"Analysis & Sensing","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Systematic evolution of ligands by exponential enrichment; Kanamycin; Chemistry; Combinatorial chemistry; Chromatography; Computational biology; Molecular biology; Biology; Biochemistry; Antibiotics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005836808,0.0009913391,0.00069821,0.000440411,0.0002598961,0.0005564566,0.0005140594,0.0004582144,0.001822012],"category_scores_gemma":[0.0006720745,0.0003043581,0.0003531678,0.0003932682,0.0002467776,0.0002938064,0.0006404744,0.0006678712,0.001484402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002526368,"about_ca_system_score_gemma":0.000192226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002102564,"about_ca_topic_score_gemma":0.0004027804,"domain_scores_codex":[0.9996119,0.00007777177,0.00003803612,0.00007481364,0.0001467186,0.00005084847],"domain_scores_gemma":[0.9997893,0.00008714513,0.00002799754,0.00002521434,0.00004654633,0.00002378347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006538699,0.0000799476,0.0001795412,0.00009793936,0.00002195638,0.0001254049,0.00004225658,0.001035677,0.9888645,0.0001445434,0.0003195535,0.009023303],"study_design_scores_gemma":[0.00001139043,0.0001087033,0.0004161927,0.000007256551,0.00001401987,0.0001947465,0.00001770342,0.00322172,0.9925368,0.00008927451,0.003367134,0.00001518152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6810355,0.002602981,0.3030833,0.0004361971,0.0002165331,0.001434947,0.002236154,0.001866372,0.007087971],"genre_scores_gemma":[0.7829819,0.002410907,0.1957131,0.0003969266,0.00003006023,0.001178047,0.00242765,0.0004411812,0.01442013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822012,"threshold_uncertainty_score":0.00609529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00983138739468,"score_gpt":0.2794927040349695,"score_spread":0.2696613166402895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}