{"id":"W4404969300","doi":"10.1007/s00792-024-01370-2","title":"Characterization of a family IV esterase from extremely halophilic archaeon Haloarcula japonica","year":2024,"lang":"en","type":"article","venue":"Extremophiles","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Dalhousie University; Daiichi-Sankyo; Japan Society for Bioscience, Biotechnology, and Agrochemistry","keywords":"Esterase; Halophile; Japonica; Biochemistry; Homology (biology); Biology; Gene; Glycerol; Hydrolysis; Strain (injury); Enzyme; Chemistry; Genetics; Botany; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119177,0.0001834937,0.000192228,0.0001020764,0.00004319035,0.00005665825,0.0001758348,0.000141358,0.00005668297],"category_scores_gemma":[0.00004849301,0.0001708605,0.0001525468,0.0001963382,0.00009638632,0.00002038953,0.00009414991,0.00007381474,0.00002653793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001409574,"about_ca_system_score_gemma":0.00007353001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004142245,"about_ca_topic_score_gemma":0.00002117862,"domain_scores_codex":[0.9987971,0.00006244579,0.0003306981,0.0004733626,0.000167453,0.0001689862],"domain_scores_gemma":[0.9993184,0.00002042084,0.00008299124,0.0004345374,0.00008037299,0.0000632837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000381394,0.00005145223,0.0002067647,0.00004317204,0.00006532943,0.000007169074,0.0001678525,0.00001294902,0.9892873,0.0001707092,0.0002110267,0.009738191],"study_design_scores_gemma":[0.0003460068,0.0001483728,0.02133014,0.0002105529,0.00007999737,0.00001042477,0.00008020461,0.001921282,0.9305796,0.000330984,0.04462003,0.0003423704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890561,0.005396381,0.004410733,0.0001854006,0.000259418,0.0001624823,0.0001621598,0.00003590287,0.0003314118],"genre_scores_gemma":[0.9943779,0.0008802383,0.0002421765,0.00009647453,0.0004044293,0.00002063805,0.003430713,0.00003913986,0.000508347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05870761,"threshold_uncertainty_score":0.6967487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770075567310329,"score_gpt":0.2486813343940139,"score_spread":0.2309805787209106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}