{"id":"W4404985326","doi":"10.1016/s0140-6736(24)02301-8","title":"Non-toxic curative option for patients with genetic disorders","year":2024,"lang":"en","type":"letter","venue":"The Lancet","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Fanconi anemia; FANCA; Context (archaeology); Medicine; Bone marrow failure; Disease; Oncology; DNA repair; Bioinformatics; Cancer research; Internal medicine; Stem cell; Haematopoiesis; Genetics; Biology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001281149,0.0005979026,0.0009685631,0.0005453344,0.001540253,0.001636682,0.0008696283,0.02647048,0.006361976],"category_scores_gemma":[0.008019895,0.0004748317,0.001033346,0.0003829227,0.002569309,0.001776314,0.001171214,0.01953313,0.003518946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002163147,"about_ca_system_score_gemma":0.001567323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001260306,"about_ca_topic_score_gemma":0.003917054,"domain_scores_codex":[0.9991937,0.0002465405,0.00007501306,0.00008612633,0.0002521426,0.0001463687],"domain_scores_gemma":[0.9973863,0.001598963,0.000168041,0.00009839553,0.0001931729,0.0005551886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003135133,0.00006589192,0.001030547,0.0001725849,0.0000413749,0.008328082,0.0000956197,0.0001903349,0.000864873,0.01045408,0.9457884,0.0326547],"study_design_scores_gemma":[0.0005027647,0.0001940019,0.001680584,0.0004008246,0.00005297064,0.0154086,0.0001568927,0.0004714541,0.0005241959,0.04103066,0.9395297,0.00004732061],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.0009971861,0.01244346,0.0002942539,0.9576033,0.02111981,0.00001357261,0.00005789133,0.00002961041,0.007440884],"genre_scores_gemma":[0.01776081,0.01028175,0.0006289337,0.8486551,0.1057764,0.00006693582,0.00009143581,0.00003597518,0.01670257],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.02647048,"threshold_uncertainty_score":0.02128285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00843316034818689,"score_gpt":0.2359428316681283,"score_spread":0.2275096713199415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}