{"id":"W4404992514","doi":"10.3390/mca29060113","title":"A Network-Based Study of the Dynamics of Aβ and τ Proteins in Alzheimer’s Disease","year":2024,"lang":"en","type":"article","venue":"Mathematical and Computational Applications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Università di Bologna; Alzheimer's Association","keywords":"Disease; Dynamics (music); Alzheimer's disease; Neuroscience; Medicine; Psychology; Computer science; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005686702,0.0004197467,0.0003037514,0.0006805304,0.0003404905,0.0006716423,0.0004601552,0.0009868047,0.001311815],"category_scores_gemma":[0.002545425,0.0001820056,0.0004653341,0.0004294198,0.0007594705,0.001377401,0.0004694388,0.0005243222,0.00008850955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008786262,"about_ca_system_score_gemma":0.0004244345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006464871,"about_ca_topic_score_gemma":0.004081728,"domain_scores_codex":[0.9998633,0.00007364959,0.000004516078,0.00002743847,0.00001395903,0.00001716817],"domain_scores_gemma":[0.9991241,0.0005713496,0.0001536669,0.00002923989,0.00005222058,0.00006950599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006378488,0.00004455774,0.003946603,0.00006699953,0.00005846612,0.0001254457,0.0001109322,0.9200892,0.002832509,0.06831598,0.000607357,0.003738173],"study_design_scores_gemma":[0.000005224537,0.00002286068,0.001356187,0.00001190336,0.000009367254,0.00002897088,0.00003046131,0.9806643,0.0001895008,0.01721008,0.000464168,0.000007072244],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7703437,0.003338197,0.2107815,0.004306095,0.00008834778,0.00003616275,0.0003596203,0.00008970877,0.01065657],"genre_scores_gemma":[0.9844514,0.001335791,0.01088575,0.0001102869,0.00003942632,0.00003238453,0.0001213603,0.00001188849,0.003011669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006464871,"threshold_uncertainty_score":0.01285446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02912385315898352,"score_gpt":0.3212781205752772,"score_spread":0.2921542674162936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}