{"id":"W4404995179","doi":"10.1038/s41380-024-02838-5","title":"X‐chromosome-wide association study for Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Occupational Cancer Research Centre; University of Toronto; McGill University; University Health Network","funders":"National Institute on Aging; Medical Research Council; Institut National de la Santé et de la Recherche Médicale; National Heart, Lung, and Blood Institute; Fondation pour la Recherche sur Alzheimer; Université de Lille; Agence Nationale de la Recherche; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease","keywords":"Pseudoautosomal region; Genetics; X chromosome; X-inactivation; Chromosome; Disease; Genetic association; Biology; Alzheimer's disease; Genome-wide association study; Y chromosome; Gene; Medicine; Genotype; Single-nucleotide polymorphism; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001510476,0.000293658,0.0003418833,0.0006994725,0.0004952465,0.000595169,0.0003462942,0.0003575038,0.003430958],"category_scores_gemma":[0.002486701,0.0001374463,0.0005438329,0.001202447,0.0002589162,0.0001910956,0.0003603148,0.0005292693,0.0002326737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001265905,"about_ca_system_score_gemma":0.0002455251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001704247,"about_ca_topic_score_gemma":0.001763449,"domain_scores_codex":[0.998807,0.0005236763,0.00009651214,0.0003436464,0.0001500648,0.00007911843],"domain_scores_gemma":[0.9982735,0.0008430328,0.0003520892,0.0001731738,0.0001536516,0.0002045446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005398681,0.00003821863,0.9893044,0.0000664368,0.001318132,0.000345176,0.0000703927,0.0001508218,0.00283971,0.0002762143,0.0004321173,0.004618485],"study_design_scores_gemma":[0.00003405281,0.0001206595,0.9965858,0.00001619263,0.0004139272,0.0005413804,0.00004245356,0.0002968872,0.0004446892,0.0001947179,0.001305072,0.000004189476],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923894,0.003297482,0.001320154,0.000223153,0.00004748059,0.00001740013,0.001048042,0.00001825827,0.001638725],"genre_scores_gemma":[0.9983847,0.0003353618,0.0003621845,0.00004414097,0.00002798948,0.000009999486,0.0004623409,0.000004626201,0.0003685882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003430958,"threshold_uncertainty_score":0.01147771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008623085990171317,"score_gpt":0.2623251348179367,"score_spread":0.2537020488277654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}