{"id":"W4405010409","doi":"10.1016/j.jad.2024.12.008","title":"Efficacy of orexin antagonists for the management of major depressive disorder: A systematic review of randomized clinical trials","year":2024,"lang":"en","type":"review","venue":"Journal of Affective Disorders","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Brain and Cognition Discovery Foundation; University Health Network","funders":"","keywords":"Randomized controlled trial; Major depressive disorder; Systematic review; Medicine; Clinical trial; MEDLINE; Psychiatry; Psychology; Clinical psychology; Internal medicine; Mood; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007251537,0.001384842,0.0102987,0.004938494,0.0004795584,0.001775131,0.001635496,0.001519902,0.005292757],"category_scores_gemma":[0.02538527,0.0008351073,0.008735064,0.005316241,0.0006841462,0.001433727,0.0009560211,0.001076672,0.0003499648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002459911,"about_ca_system_score_gemma":0.004829761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004505915,"about_ca_topic_score_gemma":0.0142677,"domain_scores_codex":[0.9945146,0.001897836,0.002235973,0.0004566854,0.0007574086,0.0001375505],"domain_scores_gemma":[0.983483,0.01082086,0.00382262,0.000257083,0.001394091,0.0002223644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001357579,0.00002601108,0.0004713793,0.9326838,0.02722618,0.00005289102,0.0000612472,0.0001122131,0.0002012966,0.0001220041,0.001204809,0.03648068],"study_design_scores_gemma":[0.00394912,0.001007064,0.005903997,0.6451997,0.3259661,0.0002794889,0.0001782343,0.0001848252,0.0003632314,0.0004705891,0.01643911,0.00005852699],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001264754,0.9972919,0.000146236,0.0002123189,0.0000988644,0.0003582307,0.0003826499,0.00001098331,0.0002341275],"genre_scores_gemma":[0.02204248,0.9752092,0.0007732215,0.000682015,0.000099476,0.000679449,0.0003536915,0.000008964058,0.0001514804],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0102987,"threshold_uncertainty_score":0.03835022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1162194085803924,"score_gpt":0.4889216084175557,"score_spread":0.3727021998371632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}