{"id":"W4405010470","doi":"10.1016/s0140-6736(24)02100-7","title":"TransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and complex or multivessel coronary disease (TCW): an international, multicentre, prospective, open-label, non-inferiority, randomised controlled trial","year":2024,"lang":"en","type":"article","venue":"The Lancet","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Royal Victoria Hospital; McGill University Health Centre","funders":"Agence Nationale de la Recherche; MicroPort; Abiomed; JenaValve; Boston Scientific Corporation; Abbott Vascular; AtriCure; Edwards Lifesciences; Medtronic; Amgen","keywords":"Medicine; Cardiology; Percutaneous coronary intervention; Conventional PCI; Fractional flow reserve; Internal medicine; Aortic valve replacement; Stenosis; Myocardial infarction; Coronary artery disease; Aortic valve stenosis; Clinical endpoint; Aortic valve; Surgery; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001890686,0.002041312,0.003901162,0.0003932943,0.0003797576,0.001563007,0.001237735,0.002635302,0.00686568],"category_scores_gemma":[0.002932783,0.0007776761,0.003129771,0.0005325952,0.001254713,0.001254492,0.0006135412,0.003632124,0.0008554359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006983752,"about_ca_system_score_gemma":0.0007517515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001290395,"about_ca_topic_score_gemma":0.00208948,"domain_scores_codex":[0.9990618,0.0005120302,0.00007184629,0.0001778583,0.0000572292,0.0001192486],"domain_scores_gemma":[0.9987817,0.0006015056,0.0002499821,0.00009620057,0.00005401656,0.0002164497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9901962,0.001129913,0.0003633646,0.0008799355,0.001775016,0.00002588405,0.00003166777,0.0001055237,0.0007400114,0.0001043964,0.0002931835,0.004354975],"study_design_scores_gemma":[0.987376,0.01010468,0.0009439436,0.00004200608,0.0009854656,0.00001694616,0.00001430241,0.0001647054,0.00007870417,0.0001100415,0.0001537673,0.000009433225],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769926,0.01353898,0.001053895,0.001161041,0.001555822,0.00198701,0.0009572672,0.0001129714,0.002640432],"genre_scores_gemma":[0.9850952,0.004803542,0.00188724,0.001639322,0.001038275,0.00212849,0.0007706308,0.00002241901,0.002614885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00686568,"threshold_uncertainty_score":0.02296799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05440128011671794,"score_gpt":0.3839033035079926,"score_spread":0.3295020233912747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}