{"id":"W4405013785","doi":"10.1016/j.jacbts.2024.10.002","title":"Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy","year":2024,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; Centre Hospitalier Universitaire Sainte-Justine; Université Laval; Montreal Children's Hospital; BC Children's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; Deutsches Zentrum für Herz-Kreislaufforschung; Great Ormond Street Hospital Charity; National Institutes of Health; Action Medical Research; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; British Heart Foundation; Medical Research Council; Deutsche Herzstiftung; Ospedale Pediatrico Bambino Gesù","keywords":"Hypertrophic cardiomyopathy; Medicine; Internal medicine; Cardiology; Cardiomyopathy; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002090397,0.0002420837,0.000466255,0.0001094222,0.000168875,0.0002224732,0.0001535009,0.0001854215,0.001578387],"category_scores_gemma":[0.0003804031,0.00004663413,0.0003971767,0.0001028533,0.0001652292,0.0001287283,0.0001233726,0.0005528603,0.0001607095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002825193,"about_ca_system_score_gemma":0.0003975935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171993,"about_ca_topic_score_gemma":0.003090246,"domain_scores_codex":[0.9998873,0.00003811313,0.00000792005,0.00001609121,0.0000141141,0.00003649719],"domain_scores_gemma":[0.9997602,0.00008868134,0.00003647306,0.0000162016,0.0000186285,0.00007981119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1753077,0.009602862,0.0759902,0.00180173,0.002337795,0.003520025,0.0003651599,0.005262531,0.210706,0.00121289,0.007189314,0.5067039],"study_design_scores_gemma":[0.01833114,0.2377525,0.5370652,0.0007386502,0.004064809,0.009016353,0.0006565187,0.004178537,0.154945,0.000827919,0.03232721,0.00009626655],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905843,0.006221419,0.0001090878,0.0002361337,0.00006038192,0.00002835647,0.0002991701,0.00002406013,0.002437182],"genre_scores_gemma":[0.9968465,0.002058043,0.0001763329,0.00009830159,0.00002179152,0.00001043075,0.0003104174,0.00000535918,0.0004728727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001578387,"threshold_uncertainty_score":0.005280256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513916535178127,"score_gpt":0.2963888892623425,"score_spread":0.2812497239105612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}