{"id":"W4405026001","doi":"10.3389/fcimb.2024.1443262","title":"Unique Leishmania mexicana clones secrete populations of extracellular vesicles with unique protein profile and variable infectious capability","year":2024,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Leishmania mexicana; Secretion; Extracellular vesicles; Biology; Microbiology; Leishmania; Extracellular; Immunology; Virology; Cell biology; Biochemistry; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131235,0.0002459119,0.0002710091,0.0003108324,0.0001977497,0.0005625847,0.0001659201,0.00032952,0.000360634],"category_scores_gemma":[0.0002373658,0.0001630365,0.0003132298,0.0002215761,0.0001328237,0.0002403794,0.000411925,0.0005109707,0.0001993676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001959998,"about_ca_system_score_gemma":0.00008408917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004631999,"about_ca_topic_score_gemma":0.0006534468,"domain_scores_codex":[0.9998528,0.00001546516,0.00002172233,0.00003043231,0.00003851549,0.00004107795],"domain_scores_gemma":[0.9997975,0.00003373359,0.00005538614,0.0000358639,0.0000491938,0.00002821968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003167687,0.00001001751,0.0008722506,0.00001484787,0.000004986084,0.0000605809,0.00002883888,0.00002809142,0.9982438,0.00003406509,0.00001766329,0.0006531905],"study_design_scores_gemma":[0.00002096822,0.000523539,0.07879259,0.00002154732,0.00008453149,0.002512467,0.0004573163,0.00162184,0.9110708,0.0001748377,0.004691172,0.00002851106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977677,0.0002319476,0.001160761,0.00004130682,0.000005315083,0.00001903227,0.0003298329,0.00002179608,0.0004223059],"genre_scores_gemma":[0.9947888,0.0002359147,0.002367367,0.00005386854,0.000006486502,0.00004650419,0.001532577,0.00002348954,0.0009449851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005625847,"threshold_uncertainty_score":0.001422048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005314184436069314,"score_gpt":0.2109126207922243,"score_spread":0.205598436356155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}