{"id":"W4405029241","doi":"10.1101/2024.12.02.623560","title":"VEXAS anemia is a mosaic erythroblastopenia","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Otitis Media and Relapsing Polychondritis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"","keywords":"Erythropoiesis; Bone marrow; Biology; Erythroblast; Somatic cell; Macrocytic anemia; Lineage (genetic); Erythropoietin; Ineffective erythropoiesis; Diamond–Blackfan anemia; Anemia; Reticulocyte; Cell biology; Immunology; Stem cell; Haematopoiesis; Genetics; Medicine; Gene; Ribosome; Internal medicine; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349265,0.0002786275,0.0001954817,0.0003752432,0.0001472309,0.0002095785,0.0000932203,0.000267507,0.002028479],"category_scores_gemma":[0.0002005308,0.00009396884,0.0001248405,0.0001418324,0.0002476828,0.00009873476,0.0002627258,0.0002545631,0.0003828182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009164506,"about_ca_system_score_gemma":0.00007925986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001724396,"about_ca_topic_score_gemma":0.0001734819,"domain_scores_codex":[0.9999033,0.00001917225,0.00001107275,0.00002614071,0.00002671594,0.0000135996],"domain_scores_gemma":[0.9999191,0.00001945283,0.00002448362,0.00001024756,0.000006088339,0.00002072063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003509081,0.00005096024,0.01255204,0.0001213916,0.00004286071,0.01713802,0.0001201341,0.0002359607,0.9520301,0.00140956,0.0009941808,0.01495379],"study_design_scores_gemma":[0.0000954455,0.0007259549,0.1640147,0.00009379402,0.00009652472,0.2320701,0.0002716579,0.003891841,0.5641924,0.003036923,0.03147584,0.00003491899],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885665,0.00139739,0.005551754,0.0001878615,0.00006152535,0.00003098794,0.0006484691,0.0003290005,0.003226539],"genre_scores_gemma":[0.9953344,0.0003844968,0.001948255,0.00006480594,0.00002157428,0.000008827878,0.0003575016,0.00003161101,0.001848319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002028479,"threshold_uncertainty_score":0.00678587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114749175067014,"score_gpt":0.2352253167100688,"score_spread":0.2240778249593987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}