{"id":"W4405029241","doi":"10.1101/2024.12.02.623560","title":"VEXAS anemia is a mosaic erythroblastopenia","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Otitis Media and Relapsing Polychondritis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"","keywords":"Erythropoiesis; Bone marrow; Biology; Erythroblast; Somatic cell; Macrocytic anemia; Lineage (genetic); Erythropoietin; Ineffective erythropoiesis; Diamond–Blackfan anemia; Anemia; Reticulocyte; Cell biology; Immunology; Stem cell; Haematopoiesis; Genetics; Medicine; Gene; Ribosome; Internal medicine; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003241194,0.0008844673,0.001169814,0.0005553974,0.0001475492,0.0003113634,0.0004498929,0.001334859,0.0005808506],"category_scores_gemma":[0.0001869077,0.0008716921,0.0004671849,0.0007366813,0.0003048517,0.00007954586,0.0008733837,0.002760513,0.002305859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005026605,"about_ca_system_score_gemma":0.001666253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007417436,"about_ca_topic_score_gemma":0.000003147386,"domain_scores_codex":[0.9958287,0.00008185134,0.0007792932,0.001623248,0.0007812244,0.0009056227],"domain_scores_gemma":[0.9966312,0.00005841916,0.0002785909,0.001903142,0.0003745843,0.0007540792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001386205,0.000485885,0.005483667,0.007011099,0.0009281352,0.00453731,0.000116117,0.000006612061,0.674969,0.0008067579,0.3054998,0.00001698757],"study_design_scores_gemma":[0.003097409,0.0005243017,0.01779931,0.01483999,0.002656864,0.000002796939,0.000009457315,0.0003976212,0.4228669,0.00003668265,0.5349427,0.002825951],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9279843,0.01911611,0.0001109829,0.005410749,0.04263845,0.001802103,0.0009066823,0.001780981,0.0002496245],"genre_scores_gemma":[0.9850131,0.001946627,0.005567202,0.002012212,0.002726298,0.0002367412,0.00000221176,0.0005185445,0.001977044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2521021,"threshold_uncertainty_score":0.9999616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114749175067014,"score_gpt":0.2352253167100688,"score_spread":0.2240778249593987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}