{"id":"W4405029650","doi":"10.1038/s41586-024-08284-1","title":"RANK drives structured intestinal epithelial expansion during pregnancy","year":2024,"lang":"en","type":"article","venue":"Nature","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council","keywords":"RANKL; Biology; Intestinal epithelium; Lactation; Epithelium; Cell biology; Stem cell; Offspring; Pregnancy; Endocrinology; Receptor; Internal medicine; Activator (genetics); Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407444,0.0001200273,0.000128749,0.0001731517,0.0001183806,0.0003235191,0.0001515401,0.0001927826,0.001426919],"category_scores_gemma":[0.0001729526,0.0001485711,0.000116568,0.00008457667,0.0002698808,0.00009582358,0.0003535572,0.0004594732,0.0005133403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003077046,"about_ca_system_score_gemma":0.0001878979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003505061,"about_ca_topic_score_gemma":0.0007000713,"domain_scores_codex":[0.9998642,0.00002803989,0.000008355462,0.00002296796,0.00003521634,0.00004119188],"domain_scores_gemma":[0.9997306,0.00005844231,0.00008827438,0.00003304442,0.00001884175,0.00007066282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000863288,0.000008503381,0.0003433782,0.00001541347,0.000001164069,0.000109453,0.0000176613,0.00003258647,0.9979406,0.000175054,0.00005612987,0.001213608],"study_design_scores_gemma":[0.00001795993,0.0003515001,0.02489526,0.000015362,0.000009848985,0.001158805,0.0001049008,0.001017508,0.9638473,0.0002361231,0.008335609,0.000009793491],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910467,0.001636938,0.002482754,0.0002677996,0.00003136302,0.00001643776,0.0004450161,0.0001457485,0.003927296],"genre_scores_gemma":[0.9944763,0.000486963,0.0007719154,0.00006151789,0.00000656614,0.00001215996,0.0002580602,0.00002010916,0.003906489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001426919,"threshold_uncertainty_score":0.004773498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00437663669610245,"score_gpt":0.2601818938795414,"score_spread":0.255805257183439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}