{"id":"W4405034526","doi":"10.1182/blood-2024-200881","title":"A Phase 3, Randomized, Double-Blind, Active-Comparator-Controlled Study of Bomedemstat Versus Hydroxyurea in Patients with Essential Thrombocythemia Naïve to Cytoreductive Therapy","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Swedish Orphan Biovitrum; RWTH Aachen University; Daiichi-Sankyo; Novartis Pharma; Galecto; Sierra Oncology; Incyte; Baxalta; Novartis Foundation; Astellas Pharma; Nippon Shinyaku; Bristol-Myers Squibb; AstraZeneca; Active Biotech; MorphoSys; Celgene; Alexion Pharmaceuticals; Ariad Pharmaceuticals","keywords":"Medicine; Essential thrombocythemia; Thrombocytosis; Internal medicine; Myelofibrosis; Anagrelide; Myeloproliferative neoplasm; Gastroenterology; Hydroxycarbamide; Oncology; Bone marrow; Surgery; Polycythemia vera; Chemotherapy; Platelet","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002069033,0.00128264,0.003518848,0.0004494635,0.0006124151,0.001054052,0.0009479604,0.002135636,0.007172086],"category_scores_gemma":[0.002466147,0.0005968735,0.001969461,0.0003687099,0.001366686,0.001326197,0.0003367259,0.003366356,0.0007708159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006911307,"about_ca_system_score_gemma":0.001302085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006691847,"about_ca_topic_score_gemma":0.001699345,"domain_scores_codex":[0.9992525,0.000394865,0.00004693605,0.0001482984,0.00005745249,0.00009996555],"domain_scores_gemma":[0.9985656,0.0004010849,0.0003229529,0.0001075446,0.0001181189,0.0004847547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9773326,0.009546634,0.0003499982,0.0004723536,0.0006939908,0.00003677138,0.00004225439,0.0001766308,0.002437056,0.00008273072,0.000583733,0.008245158],"study_design_scores_gemma":[0.9434301,0.05462724,0.0008531421,0.00001883038,0.0001960871,0.00002410609,0.00001264299,0.000254322,0.0001552202,0.00008736874,0.0003317611,0.000009120482],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773709,0.007319802,0.001286725,0.001077965,0.001309918,0.007967183,0.001318412,0.0002286319,0.002120555],"genre_scores_gemma":[0.9817005,0.002289425,0.003012916,0.002264371,0.0006606893,0.007018696,0.0009052342,0.00002910448,0.002119147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007172086,"threshold_uncertainty_score":0.02399302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260369682254912,"score_gpt":0.3358078887433011,"score_spread":0.30977092051781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}