{"id":"W4405034536","doi":"10.1182/blood-2024-207139","title":"Olverembatinib (HQP1351) Overcomes Resistance/Intolerance to Asciminib and Ponatinib in Patients (pts) with Heavily Pretreated Chronic-Phase Chronic Myeloid Leukemia (CP-CML): A 1.5-Year Follow-up Update with Comprehensive Exposure-Response (E-R) Analyses","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Ponatinib; Medicine; Internal medicine; Myeloid leukemia; Nilotinib; Gastroenterology; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001003226,0.0001800428,0.0006402389,0.0002748053,0.0001056972,0.0006198718,0.0002455415,0.0002282495,0.001001985],"category_scores_gemma":[0.0006333333,0.0001111092,0.0004704529,0.0004172662,0.0001803235,0.000442824,0.0002342218,0.0004270589,0.0001774403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005284603,"about_ca_system_score_gemma":0.0003338445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006230705,"about_ca_topic_score_gemma":0.002645605,"domain_scores_codex":[0.9996294,0.0001000253,0.00005081532,0.00007121118,0.00009339186,0.00005517129],"domain_scores_gemma":[0.9995271,0.0001136855,0.000187673,0.00003558462,0.00005140881,0.00008460624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02877859,0.001391865,0.209287,0.00106445,0.001639643,0.0003699836,0.0001875267,0.001554281,0.03294751,0.0002421544,0.005352183,0.7171848],"study_design_scores_gemma":[0.01191017,0.0599969,0.8715645,0.0001894292,0.002394045,0.003713996,0.0002148503,0.002914186,0.01329833,0.0004553241,0.03329239,0.00005580261],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852124,0.01010342,0.0005361937,0.000354709,0.00001743691,0.0002723165,0.001645755,0.00005741827,0.001800396],"genre_scores_gemma":[0.991787,0.003942678,0.0006529078,0.0004208476,0.00004383568,0.000105234,0.002251175,0.000006302969,0.0007900117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001003226,"threshold_uncertainty_score":0.005305588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01730730187031699,"score_gpt":0.2943689783184971,"score_spread":0.2770616764481801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}