{"id":"W4405034545","doi":"10.1182/blood-2024-207500","title":"T Lymphopenia and Aged Immune System Characterize Immunodeficiency in Adult Patients with Telomere Biology Disorders","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Neutropenia; Immunology; Immunodeficiency; Immunophenotyping; Medicine; Internal medicine; Lymphocytopenia; CD8; Immune system; Hypogammaglobulinemia; Lymphocyte; Gastroenterology; Biology; Antibody; Chemotherapy; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002123311,0.0002376663,0.0003349303,0.0007784112,0.0002648922,0.0003218398,0.0001484404,0.0002437027,0.001620801],"category_scores_gemma":[0.001230119,0.0001114913,0.0001188409,0.0006915462,0.00025416,0.0003193701,0.0002815615,0.0002713625,0.0002391735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001028315,"about_ca_system_score_gemma":0.0001101857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005441816,"about_ca_topic_score_gemma":0.0007251705,"domain_scores_codex":[0.9998103,0.00003165843,0.00003970766,0.00004611672,0.00002727428,0.00004503786],"domain_scores_gemma":[0.9993937,0.000128707,0.0002937123,0.00003459122,0.00004874521,0.0001006406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001101093,0.00001204248,0.9922529,0.00001652764,0.000008688186,0.00252745,0.000120885,0.00002641022,0.001118714,0.00002441505,0.000133737,0.003648157],"study_design_scores_gemma":[0.00001171281,0.0001532969,0.9709303,0.00002199946,0.0000238441,0.02749187,0.0002515789,0.0001377968,0.0003029364,0.00007221667,0.0005982167,0.000004190022],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981422,0.0008000423,0.0001421314,0.000027839,0.000004024991,0.00001119227,0.0001256503,0.000008300207,0.0007385688],"genre_scores_gemma":[0.9995,0.0001710139,0.0000813432,0.00003112958,0.00001256806,0.000003778506,0.0001186138,0.000001284153,0.00008033213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001620801,"threshold_uncertainty_score":0.005422115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003768838960564103,"score_gpt":0.2011778657915731,"score_spread":0.197409026831009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}