{"id":"W4405034804","doi":"10.1182/blood-2024-207634","title":"5-Year Follow-up of the Phase 2 Optic Study in Patients with Chronic-Phase Chronic Myeloid Leukemia: Efficacy, Safety, and First End-of-Treatment Mutational Results","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Scheme for Promotion of Academic and Research Collaboration; Sun Pharma; Otsuka Pharmaceutical; Ascentage Pharma; Ipsen Biopharmaceuticals; Ipsen; Jazz Pharmaceuticals; Bristol-Myers Squibb; Incyte; Amgen","keywords":"Medicine; Myeloid leukemia; Phases of clinical research; Phase (matter); Oncology; Internal medicine; Clinical trial; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005451077,0.0009569628,0.001913684,0.0008209015,0.0007425337,0.001613487,0.0008649502,0.001633308,0.00280777],"category_scores_gemma":[0.003420285,0.0004283579,0.002378574,0.0008849751,0.0005531083,0.001651564,0.0009590705,0.001540033,0.0008583193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001149983,"about_ca_system_score_gemma":0.001028137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002349826,"about_ca_topic_score_gemma":0.004704683,"domain_scores_codex":[0.9983549,0.0005504643,0.0001218743,0.0002696676,0.0003849905,0.0003181257],"domain_scores_gemma":[0.995864,0.0004870534,0.001655464,0.0003544723,0.0006996137,0.0009393087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2798387,0.005320007,0.6504967,0.0007302421,0.006313337,0.0004606232,0.0002833856,0.001657064,0.004253035,0.0002579348,0.01347187,0.03691724],"study_design_scores_gemma":[0.02814436,0.04449785,0.9125297,0.00009252712,0.003566026,0.0006331801,0.0001303982,0.001100456,0.0009317935,0.0001993305,0.008087136,0.00008713431],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753106,0.003031129,0.0005422881,0.0003715416,0.00008606632,0.001073774,0.01408852,0.00006877968,0.005427364],"genre_scores_gemma":[0.9560737,0.000785511,0.0007824352,0.001183929,0.0002145552,0.0009547769,0.03740775,0.00003613457,0.002561207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005451077,"threshold_uncertainty_score":0.02882844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209067028537363,"score_gpt":0.2761671150953434,"score_spread":0.2640764448099698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}