{"id":"W4405034852","doi":"10.1182/blood-2024-207798","title":"Ultra-Sensitive <i>KIT</i> testing Uncovers Previously Undetected <i>KIT</i> mutations in Patients with Indolent Systemic Mastocytosis: Results from the Pioneer Trial","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Systemic mastocytosis; Medicine; Internal medicine; Pathology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002739212,0.0002376834,0.0002984349,0.00009218711,0.0001710426,0.0000573358,0.0001623553,0.0001747231,0.00002366865],"category_scores_gemma":[0.0002743937,0.0001583617,0.0000690934,0.000440698,0.0001321425,0.00008225968,0.00003649692,0.0004458329,0.0001347394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007333215,"about_ca_system_score_gemma":0.0001652144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007832665,"about_ca_topic_score_gemma":0.0003484351,"domain_scores_codex":[0.9982751,0.0003025997,0.0005002754,0.000477794,0.00009598309,0.0003482305],"domain_scores_gemma":[0.9982981,0.001100171,0.0001506087,0.0003106384,0.0001144626,0.0000260236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1749578,0.014014,0.09367996,0.001142419,0.0107311,0.000833899,0.08535799,0.003315198,0.5765488,0.001045347,0.01267955,0.02569395],"study_design_scores_gemma":[0.712741,0.01067864,0.09558883,0.01075536,0.005006992,0.0002873602,0.007618656,0.00008581919,0.138553,0.0002059169,0.01543484,0.003043573],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946971,0.001192853,0.00004479764,0.0001011055,0.0006788377,0.001263283,0.0006968619,0.0001400989,0.001185043],"genre_scores_gemma":[0.9986842,0.0000173001,0.00006054722,0.00009881562,0.00008382673,0.00007907263,0.0006318127,0.00003161092,0.0003127654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5377831,"threshold_uncertainty_score":0.6457801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009583102273054579,"score_gpt":0.1902983011284754,"score_spread":0.1807151988554208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}