{"id":"W4405034852","doi":"10.1182/blood-2024-207798","title":"Ultra-Sensitive <i>KIT</i> testing Uncovers Previously Undetected <i>KIT</i> mutations in Patients with Indolent Systemic Mastocytosis: Results from the Pioneer Trial","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Systemic mastocytosis; Medicine; Internal medicine; Pathology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00199583,0.0004758244,0.001109296,0.0001664101,0.000163468,0.0008884523,0.0004980745,0.0008688089,0.002236326],"category_scores_gemma":[0.00252653,0.0001622244,0.001167414,0.000223862,0.0005207867,0.0007462985,0.0003404869,0.001894664,0.0004185101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005531146,"about_ca_system_score_gemma":0.0004273948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007847762,"about_ca_topic_score_gemma":0.002220377,"domain_scores_codex":[0.9993566,0.0003151257,0.00003273769,0.000106572,0.0001122844,0.00007668545],"domain_scores_gemma":[0.9986169,0.0006590899,0.000245278,0.0001122794,0.0001206483,0.0002458454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6630777,0.003203277,0.03015106,0.002283104,0.006451113,0.0005550936,0.000481037,0.001696458,0.0180073,0.001284464,0.01783912,0.2549703],"study_design_scores_gemma":[0.6399272,0.1625315,0.1330247,0.001306433,0.0129266,0.002202121,0.0002971931,0.002966056,0.003713974,0.00448942,0.03639129,0.0002235003],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514905,0.03393956,0.0008606297,0.002474229,0.0004472914,0.0005405231,0.00192882,0.0001216371,0.008196768],"genre_scores_gemma":[0.9820472,0.00707174,0.002023629,0.003326975,0.0003708158,0.0003134167,0.002721959,0.00003658934,0.002087683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002236326,"threshold_uncertainty_score":0.01055509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009583102273054579,"score_gpt":0.1902983011284754,"score_spread":0.1807151988554208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}