{"id":"W4405035165","doi":"10.1182/blood-2024-200797","title":"Renew Trial in Progress: A Phase 3, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Elritercept (KER-050) for the Treatment of Transfusion-Dependent Anemia in Adult Participants with Very Low-, Low-, or Intermediate-Risk Myelodysplastic Neoplasms (MDS)","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Placebo; Medicine; Anemia; Clinical trial; Double blind; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00237112,0.002260655,0.003866837,0.0003758028,0.000644136,0.001531925,0.001427169,0.002912961,0.01386607],"category_scores_gemma":[0.001448637,0.0007585616,0.001815049,0.0003962104,0.001561022,0.002105778,0.0004702691,0.005156653,0.002880576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006611777,"about_ca_system_score_gemma":0.001635625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000547371,"about_ca_topic_score_gemma":0.001464261,"domain_scores_codex":[0.9994692,0.0002344871,0.00003351261,0.0001192454,0.0000526409,0.00009094143],"domain_scores_gemma":[0.9991342,0.0001595665,0.0002194981,0.00008344575,0.00008725571,0.0003159664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9438242,0.01760349,0.0005712159,0.001492945,0.001277071,0.00008262326,0.0001027084,0.0003429846,0.008210594,0.0003510218,0.004027705,0.02211339],"study_design_scores_gemma":[0.9474431,0.0494585,0.0008537332,0.00003890656,0.0002443663,0.00005094817,0.0000214122,0.0002519882,0.0002957222,0.0001448572,0.00118292,0.00001353336],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9316714,0.02045211,0.004019339,0.003403632,0.002263691,0.02026905,0.008061244,0.001277089,0.008582507],"genre_scores_gemma":[0.9138784,0.01005,0.009583046,0.008811027,0.001748135,0.03099529,0.007737278,0.0002139856,0.0169829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01386607,"threshold_uncertainty_score":0.0463866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03583961702305943,"score_gpt":0.3624273305544276,"score_spread":0.3265877135313682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}