{"id":"W4405035264","doi":"10.1182/blood-2024-198737","title":"CELESTIAL-TNCLL: An Ongoing, Open-Label, Multiregional, Phase 3 Study of Sonrotoclax (BGB-11417) + Zanubrutinib vs Venetoclax + Obinutuzumab for Treatment-Naive CLL","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Obinutuzumab; Venetoclax; Ibrutinib; Medicine; Oncology; Internal medicine; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001568848,0.001042373,0.001452653,0.0005252227,0.000425662,0.001552302,0.001076266,0.001195508,0.003824996],"category_scores_gemma":[0.000789498,0.0004781632,0.001428043,0.000617617,0.0007961213,0.0008049215,0.0003232833,0.003588672,0.00104323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001062728,"about_ca_system_score_gemma":0.001482258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002153955,"about_ca_topic_score_gemma":0.006977814,"domain_scores_codex":[0.999665,0.0001486288,0.00001742234,0.00005310542,0.0000448286,0.00007110053],"domain_scores_gemma":[0.9995158,0.00005946506,0.0001096499,0.00004186045,0.00004132008,0.0002319933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6542407,0.05530009,0.005465468,0.001840437,0.002331684,0.000380145,0.0003842312,0.002273091,0.0602094,0.0004841307,0.007818474,0.2092721],"study_design_scores_gemma":[0.7416911,0.2341088,0.01012003,0.00009884559,0.0009881651,0.0004381796,0.00009046074,0.001357818,0.004856057,0.0002779718,0.005931689,0.00004079563],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800423,0.01099932,0.0008057322,0.001110585,0.0003230213,0.001775026,0.001237911,0.0003255862,0.003380549],"genre_scores_gemma":[0.980683,0.007004227,0.002113403,0.001429734,0.0002507727,0.001592751,0.002979611,0.00005707918,0.003889432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003824996,"threshold_uncertainty_score":0.01279593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1274173297696315,"score_gpt":0.445436246826477,"score_spread":0.3180189170568455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}