{"id":"W4405035333","doi":"10.1038/s41467-024-54787-w","title":"Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; York University","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Government of Canada","keywords":"Transfer RNA; Protein subunit; Biology; Methanococcus; Biochemistry; Cell biology; Archaea; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010793,0.0004686586,0.0002526416,0.0001567634,0.0006448731,0.0004144765,0.0006797707,0.0005307298,0.001579432],"category_scores_gemma":[0.0002857854,0.0003434671,0.000295908,0.0001892587,0.0003942756,0.0006755666,0.0004172372,0.001626386,0.0002172926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000735337,"about_ca_system_score_gemma":0.0003347688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003173434,"about_ca_topic_score_gemma":0.002890518,"domain_scores_codex":[0.9999465,0.000006205927,0.000002340801,0.00001299232,0.00001466876,0.0000173349],"domain_scores_gemma":[0.9998893,0.00002871245,0.00002175306,0.00001150259,0.00001988857,0.00002893108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00110286,0.000173653,0.007026518,0.0005164291,0.0001399456,0.002997007,0.001157435,0.01767634,0.9553045,0.005390906,0.002298271,0.006216177],"study_design_scores_gemma":[0.0003588333,0.0008212511,0.08421484,0.000277456,0.0002833383,0.003042175,0.003715992,0.2349634,0.6434219,0.00557208,0.02306628,0.0002624017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949939,0.0007136549,0.001863299,0.0003432361,0.00002144,0.000004957978,0.0001803764,0.00006102878,0.001818057],"genre_scores_gemma":[0.9952391,0.0006824331,0.00205807,0.00006112054,0.000008098749,0.000008173612,0.0009290126,0.00004153988,0.0009724619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003173434,"threshold_uncertainty_score":0.006309927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01557017032936895,"score_gpt":0.2966036555737427,"score_spread":0.2810334852443737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}