{"id":"W4405035355","doi":"10.1182/blood-2024-199752","title":"Monumental-6: A Phase 3 Study of Talquetamab + Pomalidomide or Talquetamab + Teclistamab Vs Elotuzumab + Pomalidomide + Dexamethasone (EPd) or Pomalidomide + Bortezomib + Dexamethasone (PVd) in Patients with Relapsed/Refractory Multiple Myeloma Who Received 1-4 Prior Lines of Therapy, Including Lenalidomide and an Anti-CD38 Monoclonal Antibody","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Pomalidomide; Dexamethasone; Bortezomib; Multiple myeloma; Medicine; Lenalidomide; Internal medicine; Refractory (planetary science); Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001927001,0.001663365,0.002201154,0.000452395,0.0004956209,0.001709029,0.001506499,0.00177198,0.008275616],"category_scores_gemma":[0.001021366,0.0007331493,0.00294137,0.000407578,0.001163703,0.001219372,0.0005579942,0.005119212,0.001979108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001238108,"about_ca_system_score_gemma":0.001634979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001209139,"about_ca_topic_score_gemma":0.003243888,"domain_scores_codex":[0.9995494,0.0001871017,0.00002178791,0.00008135071,0.00004321674,0.0001169961],"domain_scores_gemma":[0.9990968,0.0001266762,0.0001315643,0.00007605584,0.00006573414,0.000503197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8524775,0.08143849,0.001904425,0.0007249575,0.001412558,0.0001324977,0.0002263402,0.00123271,0.01437156,0.0003066661,0.002758135,0.04301414],"study_design_scores_gemma":[0.6268156,0.3632275,0.004111788,0.00004703208,0.0006322352,0.0001571919,0.00007494419,0.0007861222,0.001443805,0.0002849647,0.002387986,0.00003085381],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854711,0.004757126,0.0006437579,0.0009095296,0.0003859357,0.002961095,0.001977582,0.0001508099,0.002742978],"genre_scores_gemma":[0.9804648,0.003079325,0.001869273,0.001915417,0.0003665824,0.003395675,0.003256581,0.00006549915,0.005586879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008275616,"threshold_uncertainty_score":0.02768475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04045807147465276,"score_gpt":0.3537447381928435,"score_spread":0.3132866667181907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}