{"id":"W4405035424","doi":"10.1182/blood-2024-198579","title":"From Theory to Therapy: Evaluating Canadian Hemophilia Treatment Centres' Readiness for Gene Therapy Implementation","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; St. Michael's Hospital; University of Toronto; St. John’s Health Sciences Centre; Canadian Hemophilia Society; Hamilton Health Sciences; McMaster Children's Hospital; McMaster University; University of Ottawa; Thrombosis and Atherosclerosis Research Institute; Impact; Ottawa Hospital","funders":"","keywords":"Genetic enhancement; Medicine; Intensive care medicine; Oncology; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02649745,0.000570556,0.0005056462,0.003578702,0.008428043,0.005441535,0.003376853,0.001125642,0.003778342],"category_scores_gemma":[0.0681152,0.0006055912,0.00111382,0.003762083,0.004754033,0.001863051,0.005911453,0.002190642,0.0002746578],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.1001048,"about_ca_system_score_gemma":0.21237,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8947183,"about_ca_topic_score_gemma":0.9311139,"domain_scores_codex":[0.9808022,0.006293965,0.00116752,0.0008999148,0.007063276,0.003773004],"domain_scores_gemma":[0.9435521,0.01124831,0.007262034,0.001099232,0.02489402,0.01194435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003321453,0.000945,0.7827967,0.001369418,0.0001433828,0.0002505936,0.1022132,0.001001621,0.000444552,0.002067903,0.01038926,0.09804628],"study_design_scores_gemma":[0.00009841364,0.0007064966,0.7867501,0.001098094,0.0001149594,0.00008458403,0.1901225,0.002846962,0.0005353385,0.0004494344,0.01704991,0.0001430525],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798227,0.0005301625,0.0009219846,0.004215328,0.00006717538,0.002035109,0.0006661745,0.00004775888,0.01169359],"genre_scores_gemma":[0.9939947,0.0004144773,0.003213944,0.0004420427,0.00001026451,0.0007789198,0.0004211754,0.0000116938,0.0007127036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8998952,"threshold_uncertainty_score":0.7263147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0609348209703935,"score_gpt":0.3971974096146166,"score_spread":0.3362625886442231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}