{"id":"W4405035424","doi":"10.1182/blood-2024-198579","title":"From Theory to Therapy: Evaluating Canadian Hemophilia Treatment Centres' Readiness for Gene Therapy Implementation","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; St. Michael's Hospital; University of Toronto; St. John’s Health Sciences Centre; Canadian Hemophilia Society; Hamilton Health Sciences; McMaster Children's Hospital; McMaster University; University of Ottawa; Thrombosis and Atherosclerosis Research Institute; Impact; Ottawa Hospital","funders":"","keywords":"Genetic enhancement; Medicine; Intensive care medicine; Oncology; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003332358,0.0001164681,0.0001417004,0.0001113716,0.00009198484,0.00003870369,0.00004131688,0.0001003781,0.0003995201],"category_scores_gemma":[0.00001491316,0.00007835332,0.00007790125,0.0001513886,0.00003757247,0.0000255995,0.000004913737,0.00005560172,0.00001474498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267898,"about_ca_system_score_gemma":0.0004843078,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02002471,"about_ca_topic_score_gemma":0.006585892,"domain_scores_codex":[0.9991101,0.00004451278,0.0001752982,0.0002592224,0.0001961533,0.0002146873],"domain_scores_gemma":[0.9993936,0.0001170593,0.00002120084,0.0001617095,0.00007271721,0.0002337365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001582753,0.0001514041,0.0003832455,0.00001950387,0.0003993557,0.00001512466,0.004235427,0.00000193856,0.07662801,0.001429045,0.0003416746,0.916237],"study_design_scores_gemma":[0.03302747,0.007334274,0.06322197,0.000535984,0.001154982,0.00004534649,0.002812303,0.003247582,0.4588372,0.07412287,0.3548104,0.000849581],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745396,0.003429172,0.0008145107,0.01899447,0.0004099421,0.001400525,0.0002336787,0.00006031266,0.0001178059],"genre_scores_gemma":[0.9925069,0.0004431188,0.002860523,0.001359107,0.001149551,0.0001884499,0.0009049858,0.00003571517,0.0005516798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9153874,"threshold_uncertainty_score":0.986501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0609348209703935,"score_gpt":0.3971974096146166,"score_spread":0.3362625886442231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}