{"id":"W4405038062","doi":"10.1182/blood-2024-200017","title":"Asciminib Shows High Efficacy and Favorable Tolerability at 80 Mg Once Daily and 40 Mg Twice Daily in Patients with Chronic Phase Chronic Myelogenous Leukemia Previously Treated with 2 or More Tyrosine Kinase Inhibitors: Primary Analysis from the ASC4OPT Study","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Chronic myelogenous leukemia; Regimen; Bosutinib; Philadelphia chromosome; Adverse effect; Imatinib mesylate; Nilotinib; Gastroenterology; Imatinib; Leukemia; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001441174,0.0006384,0.001131232,0.0002792786,0.0002640414,0.0007882979,0.0003213103,0.0004742187,0.002974048],"category_scores_gemma":[0.0008345104,0.0002806759,0.001185809,0.0004177954,0.0003531205,0.0005558745,0.0002976164,0.0009825147,0.000499106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008042446,"about_ca_system_score_gemma":0.0007461793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009856715,"about_ca_topic_score_gemma":0.003057532,"domain_scores_codex":[0.999541,0.0001895229,0.00003401422,0.00008418278,0.00007453623,0.00007669551],"domain_scores_gemma":[0.9993222,0.0001269365,0.0002133646,0.0000496393,0.00005981508,0.000228092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6320955,0.01431757,0.1378786,0.001291779,0.004243254,0.0004600469,0.0002433072,0.004750328,0.04855079,0.0002139197,0.009551134,0.1464038],"study_design_scores_gemma":[0.1743607,0.3318014,0.4626769,0.0001197394,0.003337146,0.001482628,0.0001422071,0.003687935,0.0086489,0.0003647379,0.01325377,0.0001241266],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942469,0.002213157,0.0001901498,0.0001919471,0.00002646872,0.0002427976,0.001554378,0.00003613352,0.001298034],"genre_scores_gemma":[0.9952134,0.0007134529,0.0003122567,0.0002405119,0.00005702506,0.0001603746,0.002598295,0.00001157117,0.0006930634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002974048,"threshold_uncertainty_score":0.009949207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009846299612478682,"score_gpt":0.2483909284824695,"score_spread":0.2385446288699908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}