{"id":"W4405038355","doi":"10.1182/blood-2024-211761","title":"Multicenter Retrospective Analysis on the Clinical Benefit of Post-Transplant Tyrosine Kinase Inhibitor (TKI) Maintenance Therapy in Ph-Positive Acute Lymphoblastic Leukemia Suggests Improved GvHD-Free, Relapse Free Survival and Non-Relapse Mortality, but Not the Risk of Relapse","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Maintenance therapy; Oncology; Tyrosine-kinase inhibitor; Acute lymphocytic leukemia; Retrospective cohort study; Hematology; Lymphoblastic Leukemia; Progression-free survival; Overall survival; Leukemia; Immunology; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001214702,0.0001677175,0.0003582464,0.0005192752,0.0002005591,0.0003767449,0.0002151212,0.0002462082,0.00133696],"category_scores_gemma":[0.002226371,0.0001529583,0.0004785121,0.0006896644,0.0002926005,0.0002463681,0.0002869545,0.000241288,0.0001417932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843598,"about_ca_system_score_gemma":0.0002871348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005003304,"about_ca_topic_score_gemma":0.0004715206,"domain_scores_codex":[0.9992809,0.0002390037,0.0001046149,0.0001983467,0.0001162552,0.00006090692],"domain_scores_gemma":[0.9967945,0.0009106465,0.001642111,0.0002822391,0.0001676131,0.0002028717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001748862,0.00004885398,0.9934983,0.00004497713,0.0001566672,0.000145402,0.00004533664,0.0000823079,0.0003980055,0.0000267115,0.00008457641,0.003719945],"study_design_scores_gemma":[0.00009457056,0.001389176,0.9957923,0.00001416423,0.0002593318,0.001161692,0.00006112675,0.0002641649,0.0003863282,0.0000285518,0.0005429863,0.000005572785],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987966,0.0005672049,0.0001793072,0.00001010003,0.000003450963,0.00001586011,0.0002906989,0.000002901275,0.000133933],"genre_scores_gemma":[0.9992894,0.0001306103,0.00008188022,0.00001021708,0.000009573119,0.00001185635,0.0004252616,0.000001247366,0.00004002671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133696,"threshold_uncertainty_score":0.00642401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276488757747125,"score_gpt":0.282721911312692,"score_spread":0.2699570237352208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}