{"id":"W4405038508","doi":"10.1182/blood-2024-210449","title":"Retrospective Evaluation of <i>BCR::ABL</i> Kinase Domain Mutation Profiles and Treatment Outcomes in Patients with Chronic Myeloid Leukemia to Confirm Clinical Relevance of in Vitro Sensitivity-Based Treatment Switch: Real-World Experience","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Myeloid leukemia; Medicine; Oncology; Mutation; Protein kinase domain; Internal medicine; Cancer research; Immunology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001131023,0.0002428945,0.0004201036,0.001055204,0.0003607521,0.0005383986,0.0002915223,0.0004133474,0.001179077],"category_scores_gemma":[0.002099185,0.0001480728,0.000346353,0.0009598982,0.0004982547,0.0005940056,0.0004059513,0.0002577065,0.0003001839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005459049,"about_ca_system_score_gemma":0.0002965333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009040005,"about_ca_topic_score_gemma":0.0007104882,"domain_scores_codex":[0.9991955,0.0001879246,0.0001477064,0.0002197013,0.0001366741,0.000112543],"domain_scores_gemma":[0.9975222,0.0005993886,0.001080553,0.0001901432,0.0003072297,0.0003004764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002873398,0.00003656148,0.9974421,0.00001572805,0.00001641959,0.0002099216,0.00006105426,0.00006423475,0.0003338026,0.00001883886,0.0000536308,0.001460367],"study_design_scores_gemma":[0.00002323365,0.0008638322,0.9951875,0.000009436744,0.00004005489,0.002115117,0.0002340912,0.0002604233,0.0004980913,0.00003517962,0.0007227883,0.00001018039],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986821,0.0002624998,0.00011192,0.00001092552,0.000002851942,0.00003042716,0.0004311659,0.00000355976,0.000464484],"genre_scores_gemma":[0.9991685,0.00006438141,0.00007604194,0.00001472564,0.000009486818,0.00003071921,0.0005735752,0.000001791105,0.00006075504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001179077,"threshold_uncertainty_score":0.005981505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02413226950519087,"score_gpt":0.3240437313177046,"score_spread":0.2999114618125138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}