{"id":"W4405038567","doi":"10.1182/blood-2024-203957","title":"Deciphering Genotype-Phenotype Correlations and the Mechanism of the Action of Neutrophil Elastase Inhibitors during <i>ELANE</i> Associated Neutropenia Utilizing Molecular Modeling Software","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Neutrophil elastase; Neutropenia; Immunology; Phenotype; Genotype; Elastase; Biology; Medicine; Genetics; Gene; Inflammation; Enzyme; Chemotherapy; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004457924,0.0006411643,0.000521522,0.0004279334,0.0001934423,0.0005550036,0.0005188715,0.0004182577,0.00191209],"category_scores_gemma":[0.0008452914,0.0002319335,0.0007817333,0.0002854137,0.00008510221,0.0003132412,0.0002156854,0.0003712809,0.0002210548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004400162,"about_ca_system_score_gemma":0.0006300128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002814949,"about_ca_topic_score_gemma":0.002591285,"domain_scores_codex":[0.9999106,0.0000234444,0.000009250522,0.00001972485,0.0000246335,0.00001230131],"domain_scores_gemma":[0.9997811,0.0001112138,0.00005240303,0.00001388387,0.00002894288,0.00001241963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001440519,0.0005320245,0.05488466,0.0008094155,0.0007092598,0.0008936787,0.0002998111,0.7189007,0.1423309,0.006842548,0.004458956,0.06789767],"study_design_scores_gemma":[0.00005137857,0.0001680319,0.004996927,0.00002146141,0.0001150387,0.0001597678,0.00003276302,0.9713189,0.01978554,0.001075241,0.002254586,0.00002042128],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8792483,0.001052351,0.1068788,0.0004376287,0.00004114359,0.0001499811,0.003464447,0.004261915,0.004465393],"genre_scores_gemma":[0.9295228,0.001086912,0.06439991,0.00006442078,0.00000844254,0.0002322164,0.003003336,0.0003193944,0.001362745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002814949,"threshold_uncertainty_score":0.006396592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007770241874330517,"score_gpt":0.2130470177106467,"score_spread":0.2052767758363161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}