{"id":"W4405038827","doi":"10.1182/blood-2024-201513","title":"Immunotherapy with pVAX14 Nucleic Acid in Combination with All-Trans Retinoic Acid (ATRA) in an Acute Promyelocytic Leukemia (APL) Mouse Model Activates Cytotoxic T-Cells and Enhances Immune Responses: A Strategy for Turning “Cold” Tumors “Hot”","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Acute promyelocytic leukemia; Cytotoxic T cell; Retinoic acid; Tretinoin; Immune system; Cancer research; Leukemia; Immunology; Immunotherapy; Nucleic acid; Biology; Medicine; Biochemistry; Cell culture; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000353965,0.0003743079,0.0003425809,0.0001755498,0.00008876589,0.0001789457,0.0002721785,0.0002389913,0.000002657511],"category_scores_gemma":[0.00001489975,0.0003083537,0.00005946495,0.0002541987,0.0001660508,0.00006735834,0.00003029178,0.0002966027,5.052816e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008465107,"about_ca_system_score_gemma":0.0006653343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000210329,"about_ca_topic_score_gemma":0.0000881271,"domain_scores_codex":[0.9981418,0.000112564,0.0003774705,0.0007272117,0.0001925086,0.000448464],"domain_scores_gemma":[0.9993668,0.00003563367,0.0001164325,0.000332662,0.00007446342,0.00007396925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00218584,0.0002378275,0.0002504071,0.0002788946,0.0001705266,0.00004656356,0.0009003608,0.0007887547,0.9946963,0.00005220348,0.000002396299,0.0003899595],"study_design_scores_gemma":[0.004508842,0.003152489,0.0001727948,0.0003305962,0.00008746076,0.0000550642,0.0004205173,0.004146361,0.9865251,0.0001128968,0.00003346989,0.0004544715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942136,0.002580935,0.002090084,0.00003875573,0.00002320135,0.0009274664,0.00003473157,0.0000522299,0.00003896499],"genre_scores_gemma":[0.9959507,0.0008852339,0.002205699,0.00004098853,0.00003970412,0.000382404,0.0001368583,0.00009712575,0.0002613122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00817123,"threshold_uncertainty_score":0.9999369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008806819354933864,"score_gpt":0.2475471334518146,"score_spread":0.2387403140968807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}