{"id":"W4405038827","doi":"10.1182/blood-2024-201513","title":"Immunotherapy with pVAX14 Nucleic Acid in Combination with All-Trans Retinoic Acid (ATRA) in an Acute Promyelocytic Leukemia (APL) Mouse Model Activates Cytotoxic T-Cells and Enhances Immune Responses: A Strategy for Turning “Cold” Tumors “Hot”","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Acute promyelocytic leukemia; Cytotoxic T cell; Retinoic acid; Tretinoin; Immune system; Cancer research; Leukemia; Immunology; Immunotherapy; Nucleic acid; Biology; Medicine; Biochemistry; Cell culture; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002101993,0.0006922355,0.0003366826,0.0005639545,0.0001503704,0.0002932403,0.0003204189,0.0005468633,0.001238967],"category_scores_gemma":[0.0000708509,0.0001917503,0.0004712141,0.000222194,0.0004083318,0.000284381,0.0001812136,0.00127934,0.0004162651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002097085,"about_ca_system_score_gemma":0.0002523395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002180183,"about_ca_topic_score_gemma":0.0002545133,"domain_scores_codex":[0.9998049,0.00002713187,0.00001672391,0.00004519255,0.00005613629,0.00004993989],"domain_scores_gemma":[0.9998678,0.00001795788,0.00005177157,0.0000174639,0.000008766859,0.00003616814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002565284,0.0002056004,0.000100688,0.00002964294,0.000005082329,0.00003086894,0.00001343633,0.0001191486,0.9979539,0.00008694575,0.00003211754,0.001166061],"study_design_scores_gemma":[0.00006281273,0.002491387,0.0005605178,0.000004924154,0.00001852305,0.0001289788,0.000009738907,0.0004937063,0.995438,0.00003030143,0.0007585093,0.000002591595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940201,0.0007061107,0.00332025,0.0001447797,0.00007227967,0.0001088669,0.0002646042,0.0002160259,0.001146883],"genre_scores_gemma":[0.9887071,0.0008332017,0.005213922,0.0000568638,0.00003617258,0.0002023684,0.0005190676,0.00003422681,0.004397125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238967,"threshold_uncertainty_score":0.004144788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008806819354933864,"score_gpt":0.2475471334518146,"score_spread":0.2387403140968807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}