{"id":"W4405038834","doi":"10.1182/blood-2024-201022","title":"ASC4REAL: Efficacy and Tolerability Comparison between Ascembl Study, a Phase 3 Randomized Clinical Trial (RCT), and Consolidated Real-World (RW) Evidence with Asciminib in CML Patients Beyond 2 TKIs","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Randomized controlled trial; Tolerability; Medicine; Internal medicine; Adverse effect","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02582271,0.001496212,0.002485915,0.001104713,0.0005975068,0.001912254,0.001046752,0.001748571,0.01791735],"category_scores_gemma":[0.02701679,0.0005795051,0.006869202,0.001535017,0.001063617,0.00198228,0.001468908,0.002767792,0.001173086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001501362,"about_ca_system_score_gemma":0.002987174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007539292,"about_ca_topic_score_gemma":0.002212096,"domain_scores_codex":[0.9834777,0.01223529,0.001722322,0.001035978,0.001069186,0.0004595309],"domain_scores_gemma":[0.9781058,0.009479144,0.00811059,0.001694003,0.0016665,0.0009438209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8806858,0.00332338,0.01142857,0.01437225,0.03963276,0.0001212189,0.0002555357,0.001512311,0.001874016,0.001712792,0.008037266,0.03704416],"study_design_scores_gemma":[0.7897988,0.07498255,0.0372764,0.002805023,0.05815062,0.0003449291,0.0003444137,0.002317162,0.001486089,0.002927128,0.02941906,0.0001477905],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7837815,0.06215014,0.01174575,0.004664252,0.001570496,0.05248043,0.06138971,0.0005550497,0.02166255],"genre_scores_gemma":[0.9251003,0.00581259,0.01008695,0.002814353,0.0004996224,0.03462847,0.01827557,0.0001026668,0.002679498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02582271,"threshold_uncertainty_score":0.1365652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07919037351382231,"score_gpt":0.4299993825019653,"score_spread":0.350809008988143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}