{"id":"W4405038934","doi":"10.1182/blood-2024-198359","title":"Satisfy: A Eurobloodnet Multicenter, Single-Arm Phase 2 Trial of Mitapivat in Adult Patients with Erythrocyte Membranopathies and Congenital Dyserythropoietic Anemia Type II - Results from the 8-Week Dose-Escalation Period","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Anemia; Internal medicine; Surgery; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001726897,0.001548544,0.001395033,0.0004144903,0.000326302,0.0009630031,0.0007431137,0.001306074,0.008464663],"category_scores_gemma":[0.0009317474,0.0003639842,0.001020846,0.0003742619,0.0006409883,0.001114523,0.0004561454,0.002291028,0.001378004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005693335,"about_ca_system_score_gemma":0.0008792354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003600231,"about_ca_topic_score_gemma":0.0009585191,"domain_scores_codex":[0.9996454,0.000193608,0.00001558927,0.00005246667,0.00003057655,0.00006233858],"domain_scores_gemma":[0.9995613,0.00005917489,0.0001024717,0.00003435919,0.00003968183,0.0002030628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8760058,0.01926499,0.00410435,0.001068218,0.001375168,0.0001868653,0.0001207867,0.001546142,0.0145111,0.0004963269,0.008410573,0.07290961],"study_design_scores_gemma":[0.8277139,0.1566607,0.007880942,0.00006637345,0.0004211647,0.00029644,0.00004890861,0.0006369384,0.001059252,0.0002655634,0.004925408,0.00002443585],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761645,0.007142806,0.001289792,0.00191952,0.0005091885,0.004276677,0.003259782,0.0002775264,0.005160202],"genre_scores_gemma":[0.9665207,0.004387064,0.003410267,0.003547985,0.0004661215,0.00773275,0.006238454,0.00009372806,0.007602875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008464663,"threshold_uncertainty_score":0.02831709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722865127318473,"score_gpt":0.2461420264597059,"score_spread":0.2289133751865211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}