{"id":"W4405038934","doi":"10.1182/blood-2024-198359","title":"Satisfy: A Eurobloodnet Multicenter, Single-Arm Phase 2 Trial of Mitapivat in Adult Patients with Erythrocyte Membranopathies and Congenital Dyserythropoietic Anemia Type II - Results from the 8-Week Dose-Escalation Period","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Anemia; Internal medicine; Surgery; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129285,0.0002499851,0.0004262025,0.0001184144,0.0001005471,0.00003672612,0.00007270863,0.0001460687,0.00006353801],"category_scores_gemma":[0.0004528647,0.0001661797,0.00006077887,0.0004054938,0.0002727915,0.0001336414,0.00006454394,0.0003020575,0.00001082946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002688479,"about_ca_system_score_gemma":0.0001173344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001597008,"about_ca_topic_score_gemma":0.0002108053,"domain_scores_codex":[0.9982853,0.0001496872,0.0005633947,0.0004726645,0.0002971939,0.0002317798],"domain_scores_gemma":[0.9988923,0.000311684,0.0001459975,0.0003201177,0.0002376127,0.00009226397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6439723,0.05401425,0.03254089,0.001080464,0.00168578,0.0007595737,0.04056834,0.00002018052,0.2068326,0.0003037256,0.00159852,0.01662329],"study_design_scores_gemma":[0.7905363,0.0682724,0.1149293,0.001811206,0.002423423,0.0001120558,0.002022003,0.0009547096,0.01667364,0.00009061185,0.001441719,0.0007325537],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964941,0.0007173923,0.000005874955,0.0005421782,0.0006113555,0.0009748324,0.000261884,0.00007204849,0.0003203577],"genre_scores_gemma":[0.9984655,0.0001524244,0.0003101196,0.000184388,0.0002510659,0.00001899431,0.0005113725,0.00003810873,0.00006798877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.190159,"threshold_uncertainty_score":0.6776611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722865127318473,"score_gpt":0.2461420264597059,"score_spread":0.2289133751865211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}