{"id":"W4405039042","doi":"10.1182/blood-2024-209732","title":"Real-World Clinical Outcomes for Complement Inhibitor Experienced and Naïve Paroxysmal Nocturnal Hemoglobinuria Patients Prescribed Pegcetacoplan in Europe and Canada","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Complement (music); Eculizumab; Pediatrics; Internal medicine; Immunology; Complement system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006649665,0.0002711616,0.0003818106,0.001244095,0.001138323,0.001320659,0.000914524,0.0004920761,0.001199142],"category_scores_gemma":[0.002272188,0.0001645993,0.0005825934,0.003140521,0.0005454359,0.0003447117,0.0007368993,0.0006394906,0.0001510693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01723586,"about_ca_system_score_gemma":0.0115503,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9288426,"about_ca_topic_score_gemma":0.9400195,"domain_scores_codex":[0.9988863,0.00009383809,0.000099224,0.00018896,0.0003713465,0.0003603225],"domain_scores_gemma":[0.9965161,0.0001983762,0.001121844,0.00005413428,0.0009848389,0.001124725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000143863,0.00003292851,0.9969463,0.00002707737,0.0000714549,0.0001163784,0.0001867104,0.0001353094,0.00005321819,0.00005218552,0.0006684182,0.001566201],"study_design_scores_gemma":[0.00001729423,0.00003733209,0.9986168,0.00001943602,0.00002411185,0.0001333544,0.0004213171,0.0001946605,0.00003136505,0.000009598927,0.0004856592,0.000009066578],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884143,0.0009240685,0.00004094216,0.0002691404,0.00000996219,0.00004528571,0.007790741,0.000006702844,0.002498828],"genre_scores_gemma":[0.9944403,0.0006178256,0.0001067011,0.0001815351,0.0000101312,0.00002411774,0.004248681,0.000003720431,0.0003670399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0711574,"threshold_uncertainty_score":0.1431528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.023785198260685,"score_gpt":0.3029364197729831,"score_spread":0.2791512215122981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}