{"id":"W4405039089","doi":"10.1182/blood-2024-211173","title":"Replication Stress Induces Hyper-Apobec Mutagenesis in Multiple Myeloma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; Terry Fox Research Institute","funders":"","keywords":"APOBEC; Mutagenesis; Biology; Genetics; Replication (statistics); Mutation; Virology; Genome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817713,0.0002859852,0.0002739235,0.0004571845,0.0003879324,0.0005352653,0.0001308823,0.0003532865,0.001891358],"category_scores_gemma":[0.000284807,0.000141585,0.0003329952,0.0008335111,0.0002304841,0.0001886285,0.0003787648,0.0003150483,0.0002732956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004530186,"about_ca_system_score_gemma":0.0002928103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002474057,"about_ca_topic_score_gemma":0.002229863,"domain_scores_codex":[0.9998361,0.00001403899,0.00001142098,0.00006727006,0.00004440529,0.00002671721],"domain_scores_gemma":[0.9998171,0.00003570727,0.00008930987,0.00001658786,0.00002105661,0.0000202983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005519644,0.00004360361,0.186345,0.0003197271,0.0001974596,0.0005330711,0.0001710498,0.0008762845,0.7942442,0.0002324891,0.0005562173,0.01592884],"study_design_scores_gemma":[0.00001697152,0.0001932679,0.9368083,0.00003273749,0.0001052163,0.001551381,0.0002358628,0.002470043,0.054057,0.0005826743,0.003931121,0.00001539127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938214,0.001708289,0.001188233,0.0000729501,0.000008511031,0.00001645762,0.00254474,0.00009554623,0.0005438871],"genre_scores_gemma":[0.9949065,0.0006456718,0.001224429,0.00008547299,0.000008697175,0.00002257301,0.002477811,0.00001256845,0.0006162918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002474057,"threshold_uncertainty_score":0.006327152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04264487445024339,"score_gpt":0.3185730967213846,"score_spread":0.2759282222711412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}