{"id":"W4405039389","doi":"10.1182/blood-2024-208314","title":"Metabolic and Cell Cycle Proteins As Novel Targets of Selinexor Activity in Diffuse Large B Cell Lymphoma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Diffuse large B-cell lymphoma; Lymphoma; Cell cycle; Computational biology; Cell; Biology; Cell biology; Cancer research; Medicine; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009830176,0.0002688314,0.0003187484,0.0004154448,0.0001598869,0.0003023925,0.0001332869,0.0002205008,0.0009133831],"category_scores_gemma":[0.00007802869,0.0001026918,0.0002854474,0.0004079074,0.0001348442,0.0001837995,0.0001197484,0.000225808,0.0002134768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002454345,"about_ca_system_score_gemma":0.000106535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004712054,"about_ca_topic_score_gemma":0.0009126694,"domain_scores_codex":[0.9999363,0.000007489215,0.000004681413,0.00001655077,0.00002295661,0.0000120005],"domain_scores_gemma":[0.9999483,0.000007158376,0.00001976572,0.000002891738,0.00001043036,0.00001143685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000477666,0.00003139626,0.002639939,0.0001552196,0.00003068187,0.0001452917,0.00002152966,0.000134243,0.9928489,0.00002859377,0.00008154156,0.003404972],"study_design_scores_gemma":[0.00009468386,0.0008487921,0.1657089,0.00002633602,0.0001496719,0.001440312,0.0001678621,0.002845615,0.8222545,0.0001297774,0.006314871,0.00001873247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902357,0.006667706,0.001136264,0.00009144375,0.00001608804,0.00002390043,0.001081894,0.0000644278,0.0006825194],"genre_scores_gemma":[0.9891026,0.004115551,0.002850782,0.0001229313,0.00001559954,0.00005097672,0.002264347,0.00001566256,0.001461479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009133831,"threshold_uncertainty_score":0.003055573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005173776696513386,"score_gpt":0.2224412656004852,"score_spread":0.2172674889039719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}