{"id":"W4405040167","doi":"10.1182/blood-2024-210782","title":"Multi-Pronged Effects of Cohesin Mutations in the Myeloid Leukemia of Down Syndrome","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Myeloid leukemia; Cohesin; Cancer research; Genetics; Mutation; Leukemia; Medicine; Myeloid; Biology; Gene; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167327,0.0002628421,0.0002620731,0.0002642923,0.0001766156,0.0002484183,0.0001872303,0.0003821186,0.001737311],"category_scores_gemma":[0.0001534643,0.000148083,0.0002489027,0.0001413782,0.00020367,0.00008887865,0.0003780855,0.0005911779,0.0002573919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001791726,"about_ca_system_score_gemma":0.0001692369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001045252,"about_ca_topic_score_gemma":0.001359578,"domain_scores_codex":[0.9998406,0.00002378265,0.00002619097,0.00004101733,0.00004619943,0.00002213217],"domain_scores_gemma":[0.9998931,0.00003001507,0.00002747669,0.000008032537,0.00000541206,0.00003599278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001619953,0.00005597506,0.001267081,0.00006363029,0.0000164383,0.00159311,0.00005012402,0.0001268182,0.9921076,0.0002086253,0.00006489815,0.004283661],"study_design_scores_gemma":[0.00009943732,0.00159022,0.04702397,0.00003717044,0.000150254,0.0113866,0.0001990354,0.001486268,0.927837,0.0001488437,0.01001184,0.00002953307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953879,0.0006985244,0.001826715,0.0000942904,0.00004209097,0.00005243954,0.0005077048,0.00005127072,0.001339209],"genre_scores_gemma":[0.9960737,0.0006811882,0.001434441,0.00004434134,0.000004515598,0.00002279295,0.0002741067,0.00002027829,0.001444547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737311,"threshold_uncertainty_score":0.00581181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248153017568844,"score_gpt":0.2660339515104317,"score_spread":0.2535524213347433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}