{"id":"W4405040288","doi":"10.1182/blood-2024-200747","title":"An Erythroid-Specific Lentiviral Vector Improves Anemia and Iron Metabolism in a New Model of Xlsa","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Virology; Viral vector; Anemia; Medicine; Biology; Computational biology; Internal medicine; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003376221,0.0006911453,0.0005713917,0.0006221137,0.0002506827,0.0005490404,0.0005169792,0.000778168,0.002333782],"category_scores_gemma":[0.0001564449,0.0002252614,0.000397315,0.0002133311,0.0003903822,0.00045197,0.0002558183,0.00170715,0.0004034538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002981176,"about_ca_system_score_gemma":0.0003137405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005454136,"about_ca_topic_score_gemma":0.0006404076,"domain_scores_codex":[0.9997186,0.00003202021,0.00004190594,0.00007242961,0.00008992374,0.00004494029],"domain_scores_gemma":[0.9997546,0.0000266324,0.00007116945,0.00002185993,0.00002505046,0.0001007423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002709277,0.0003170902,0.0001064597,0.00007228057,0.00001365879,0.0001139045,0.0000338295,0.0001192137,0.9958704,0.0003584893,0.0001965599,0.002527174],"study_design_scores_gemma":[0.0003269067,0.00353358,0.003156,0.00005945117,0.0001212481,0.001065563,0.0001047889,0.004118937,0.9762717,0.0002846766,0.01093227,0.00002474335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787836,0.002453693,0.01249986,0.0005776486,0.0003200984,0.0001559888,0.001358788,0.0006431869,0.003207175],"genre_scores_gemma":[0.970529,0.002531054,0.009293865,0.0002973063,0.00007956399,0.0003061388,0.002114652,0.0001571725,0.01469122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002333782,"threshold_uncertainty_score":0.007807314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01921340387184822,"score_gpt":0.2569520739891047,"score_spread":0.2377386701172565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}