{"id":"W4405040692","doi":"10.1182/blood-2024-199174","title":"First Results from the Dose Escalation Part of the Phase 1 Study of KTX1001, an Oral, First-in-Class, Potent Inhibitor of MMSET/NSD2 for Relapsed/Refractory Multiple Myeloma (RRMM)","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Multiple myeloma; Medicine; Lenalidomide; Internal medicine; Class (philosophy); Refractory (planetary science); Oncology; Physics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001449752,0.00132154,0.001283324,0.0004026598,0.0004043088,0.0008458856,0.0009513656,0.001401111,0.005094063],"category_scores_gemma":[0.001086701,0.0004466478,0.00087881,0.0004017207,0.0005498488,0.0005904504,0.0003619337,0.004070729,0.001269745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001039568,"about_ca_system_score_gemma":0.001450692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001500591,"about_ca_topic_score_gemma":0.004054844,"domain_scores_codex":[0.9995412,0.0001896434,0.00002110418,0.00006625124,0.00009261115,0.00008924445],"domain_scores_gemma":[0.998904,0.0002537542,0.0001853753,0.0001036898,0.0001198664,0.0004332069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2642789,0.1245742,0.01847157,0.001587017,0.002777728,0.001149285,0.0007261744,0.007812207,0.1937428,0.0008199615,0.06232293,0.3217373],"study_design_scores_gemma":[0.2109016,0.6370211,0.05803896,0.0001609245,0.001713727,0.001972349,0.0001689982,0.003258955,0.04612235,0.001025219,0.03950632,0.0001095392],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9518636,0.00505582,0.003088148,0.002023923,0.0002184292,0.006042287,0.01903063,0.0005440302,0.01213311],"genre_scores_gemma":[0.9299796,0.004576792,0.009130904,0.004226703,0.000231432,0.004627409,0.03220747,0.0002367624,0.01478282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005094063,"threshold_uncertainty_score":0.01704133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02047918779872972,"score_gpt":0.264486604641157,"score_spread":0.2440074168424272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}